Clearly conserved segments of BRCA1
| Conserved segment | Reference | Begin | End | Number of invariant residues | Number deleterious | |
|---|---|---|---|---|---|---|
| known | classified “probable” | |||||
| RING finger | 26 | 11 | 98 | 36 | 11 | 9 |
| motif 3 | 27 | 378 | 388 | 4 | 0 | 0 |
| motif 4 | 27 | 458 | 467 | 3 | 0 | 1 |
| motif 6 | 27 | 845 | 869 | 9 | 0 | 3 |
| motif 7 | 27 | 1147 | 1153 | 4 | 0 | 1 |
| coiled coil | 28 | 1369 | 1418 | 16 | 0 | 2 |
| BRCT repeat 1 | 29 | 1650 | 1753 | 40 | 4 | 22 |
| BRCT repeat 2 | 29 | 1760 | 1855 | 17 | 1 | 12 |