BREAST-OVARIAN Non-Jewish families
|
High risk breast-ovarian
| Any of the following: |
1 case of breast cancer ⩽40 y in an FDR or SDR |
| 1 FDR or SDR with both breast and ovarian cancer, at any age |
| ⩾2 cases of breast cancer in FDRs or SDRs if one is diagnosed at ⩽50 y or is bilateral |
| 1 FDR or SDR with breast cancer diagnosed at ⩽50 y or bilateral and 1 FDR or SDR with ovarian cancer |
| 3 cases of breast and ovarian cancer (at least one case of ovarian cancer) in FDRs and SDRs |
| 2 cases of ovarian cancer in FDRs and SDRs |
| 1 case of male breast cancer in an FDR or SDR if another FDR or SDR has (male or female) breast or ovarian cancer |
Moderate risk breast
| Any of the following: |
2 FDRs if both diagnosed between 51 and 60 y |
| 1 FDR and SDR (mother or sister and maternal aunt or maternal grandmother), if sum of their ages is ⩽118 y |
Moderate risk ovarian
| 1 FDR with ovarian cancer |
BREAST-OVARIAN Jewish families
|
High risk breast-ovarian
| Any of the following: |
⩾1 case of breast cancer ⩽50 y in an FDR or SDR |
| ⩾1 case of ovarian cancer at any age in an FDR or SDR |
| ⩾1 FDR or SDR with breast cancer at any age if another FDR or SDR has breast and/or ovarian cancer at any age |
| ⩾1 case of male breast cancer in an FDR or SDR |
COLON
|
High risk HNPCC
| Any of the following: |
| 3 FDRs or SDRs affected with any HNPCC associated cancers*; all cases can occur in one generation, no age restriction |
| 1 FDR or SDR with two or more HNPCC associated cancers* |
| 1 FDR with CRC <50 y |
Moderate risk colon
| 1 FDR with CRC ⩾50 and one SDR with CRC at any age |
| 2 FDRs with CRC ⩾50 at any age |
POLYPOSIS
|
Polyposis
| Any FDR or SDR with >10 polyps |
PROSTATE
|
High risk prostate
| Any of the following: |
| 3 relatives affected, any age |
| 2 relatives affected (2 FDRs or 1 FDR and 1 SDR), one diagnosed at <60 y |
Moderate risk prostate
| Any of the following: |
| 1 FDR diagnosed at <60 y |
| 2 FDRs with PC diagnosed at >60 y |
| 1 FDR and one SDR with PC diagnosed at >60 y |
MELANOMA
|
High risk melanoma
| 3 FDRs or SDRs affected with melanoma and or pancreatic cancer, at least two generations (must include more than one case of melanoma) |
| 1 FDR or SDR with multiple primary melanomas |
Moderate risk melanoma
| ⩾1 FDR with melanoma |
LI-FRAUMENI SYNDROME
|
High risk Li-Fraumeni
| All of the following: |
| 1 FDR or SDR with sarcoma, brain, or adrenal cancer diagnosed at <45 y; and |
| 1 FDR or SDR with sarcoma, breast, brain, adrenal or leukaemia at any age; and |
| 1 FDR or SDR with any cancer diagnosed at <60 y |
MULTIPLE ENDOCRINE NEOPLASIAS/THYROID CANCER
|
High risk MEN 1
| 2 cases of pancreatic (islet cell) cancer, parathyroid (hyperplasia) and/or pituitary adenoma in FDRs or SDRs (can be same person) |
High risk thyroid/MEN 2
| Any of the following: |
| 2 cases of thyroid cancer in FDRs or SDRs |
| 1 FDR or SDR with thyroid cancer and 1 FDR or SDR with parathyroid (hyperplasia) or adrenal cancer (can be same person) |
Moderate risk thyroid
| 1 FDR with thyroid cancer |
FAMILIAL AGGREGATION OF OTHER CANCERS
|
High risk cluster
| Any of the following: |
| 3 cases of the following cancers in one genetic lineage: bladder, brain, endometrial, oesophageal, kidney, lung, mouth or throat, multiple myeloma, pancreatic, sarcoma, stomach, other skin cancers, testicular, haematological malignancies (in FDRs or SDRs) |
SINGLE CASES OF CANCER REQUIRING CANCER GENETICS CONSULTATION
|
A single case of:
| Medullary thyroid cancer, adrenocortical carcinoma, phaeochromocytoma, paraganglioma, Wilms’ tumour, or retinoblastoma |