Univariate and multivariable analysis of concerns about genetic testing among HNPCC, FAP, and HBOS syndromes: fear of discrimination subscale
| Fear of discrimination subscale | n | FOD score, mean (SD) | P value |
|---|---|---|---|
| Cohort | |||
| HNPCC | 37 | 15.27 (4.28) | |
| FAP | 26 | 15.07 (5.12) | |
| HBOS | 67 | 14.08 (4.12) | 0.35* |
| Age | |||
| <40 years | 52 | 15.48 (4.75) | |
| >40 years | 76 | 14.01 (4.07) | 0.06 |
| Gender | |||
| Female | 105 | 14.30 (4.40) | |
| Male | 24 | 15.87 (4.17) | 0.11 |
| Disease status | |||
| Affected | 67 | 13.92 (4.34) | |
| Unaffected | 63 | 15.36 (4.33) | 0.06 |
| Education | |||
| >College | 84 | 14.92 (4.01) | |
| <College | 45 | 13.97 (5.01) | 0.24 |
| Income | |||
| <$75 000 | 52 | 14.15 (5.00) | |
| >$75 000 | 70 | 14.84 (3.93) | 0.39 |
| Partner | |||
| No | 38 | 14.26 (5.23) | |
| Yes | 91 | 14.73 (4.01) | 0.57 |
| Having children | |||
| No | 31 | 14.16 (5.13) | |
| Yes | 98 | 14.73 (4.14) | 0.52 |
| Risk perception of cancer | |||
| High, very high | 89 | 15.11 (4.52) | |
| Average, low, very low | 35 | 13.51 (4.08) | 0.07 |
| Perception of test results | |||
| Have an altered gene | 84 | 14.64 (4.46) | |
| Do not have an altered gene | 27 | 14.33 (3.80) | 0.74 |
| Multiple linear regression analysis | Regression coefficient | P value |
|---|---|---|
| *Comparisons post-hoc (HNPCC, P = 0.38; FAP, P = 0.59; Tukey’s test); †the reference group is HBOS. | ||
| Intercept | 10.82 | |
| HNPCC† | 1.57 | 0.10 |
| FAP† | 2.08 | 0.07 |
| Age (>40 years) | −0.81 | 0.32 |
| Gender (female) | −1.36 | 0.18 |
| Education (>college) | 1.67 | 0.06 |
| Disease status (unaffected) | 1.78 | 0.03 |
| Risk perception of cancer (high, very high) | 2.18 | 0.01 |