Table 8

Area under the ROC curve (C-statistic) for each model using a 10% detection prediction in 175 (174 for BRCA1 models) samples with full gene testing

Test result variable(s)	C-statistic	95% Confidence interval
Test result variable(s)	C-statistic	Lower bound	Upper bound
The entire set of 258 samples could not be used as scores for Frank1 in particular could not be derived for many samples.
BRCA1 models
Frank1 BRCA1	0.392	0.164	0.621
Couch BRCA1	0.500	0.323	0.677
Manchester BRCA1	0.669	0.417	0.921
BRCAPRO BRCA1	0.607	0.335	0.880
BRCA2 models
Frank1 BRCA2	0.399	0.244	0.555
Manchester BRCA2	0.817	0.735	0.899
BRCAPRO BRCA2	0.533	0.399	0.667
BRCA1 and 2 models
Frank2 combined	0.714	0.599	0.829
Manchester combined	0.772	0.670	0.875
BRCAPRO combined	0.596	0.457	0.735