Proportion of pathogenic mutations predicted in both genes by scoring in the combined dataset (sets 1 and 2)
| Manchester score | BRCA1 | BRCA2 |
|---|---|---|
| 25+ | 40/51 (78%) | 9/12 (75%) |
| 20–24 | 21/42 (50%) | 7/14 (50%) |
| 15–19 | 36/99 (36%) | 20/61 (33%) |
| 12–14 | 20/101 (20%) | 15/71 (21%) |
| 10–11 | 9/76 (11.8%) | 10/64 (15.6%) |
| 8–9 | 4/104 (3.8%) | 3/70 (4.3%) |
| 1–7 | 2/141 (1.4%) | 3/136 (2.2%) |
| Total | 132/614 (21.4%) | 67/428 (15.7%) |