Risk (odds ratio) of NTD in NTD cases and NTD case mothers at seven candidate gene loci
| NTD cases | NTD case mothers | |||||
|---|---|---|---|---|---|---|
| OR | [95% CI] | p value | OR | [95% CI] | p value | |
| MTHFR 677C→T | ||||||
| CC v CT+TT | 2.03 | [1.09, 3.79] | 0.025 | 0.72 | [0.37, 1.39] | |
| MTHFR 1298A→C | ||||||
| AA v AC+CC | 1.63 | [0.89, 3.00] | 1.55 | [0.83, 2.88] | ||
| MTRR 66A→G | ||||||
| AA v AG+GG | 0.31 | [0.10, 0.94] | 0.04 | 0.46 | [0.19, 1.09] | |
| GCPII 1561C→T | ||||||
| CC v CT+TT | 1.05 | [0.53, 2.09] | 1.09 | [0.59, 2.02] | ||
| CβS 844ins68 | ||||||
| WW v WI+II | 1.27 | [0.53, 3.02] | 1.22 | [0.56, 2.69] | ||
| RFC-1 80G→A | ||||||
| GG v GA+AA | 1.29 | [0.65, 2.55] | 0.69 | [0.35, 1.36] | ||
| SHMT 1420C→T | ||||||
| CC v CT+TT | 0.92 | [0.67, 1.27] | 0.64 | [0.36, 1.14] | ||