Frequency of the GAGC haplotype in children with wheezing and/or sensitisation
| Haplotype† | No wheezing | Wheezing | |||||
|---|---|---|---|---|---|---|---|
| No sensitisation (controls, n = 385) | Sensitisation (n = 131) | No sensitisation (n = 370) | Sensitisation (n = 154) | ||||
| Frequency | Frequency | OR (95% CI)* | Frequency | OR (95% CI)* | Frequency | OR (95% CI)* | |
| *Odds ratio and 95% CI of having one or two GAGC haplotypes in cases v controls (boys and girls analysed separately) using a multinomial logistic regression model; †haplotype of four SNPs. “0 GAGC” indicates that the individual does not have the haplotype and “1 or 2 GAGC” that the individual has one or two such haplotypes. | |||||||
| Boys | (n = 174) | (n = 72) | (n = 213) | (n = 101) | |||
| 0 GAGC | 60.9% | 72.2% | 1.00 | 78.9% | 1.00 | 69.3% | 1.00 |
| 1 or 2 GAGC | 39.1% | 27.8% | 0.60 (0.33 to 1.09) | 21.1% | 0.42 (0.27 to 0.65) | 30.7% | 0.69 (0.41 to 1.16) |
| Girls | (n = 211) | (n = 59) | (n = 157) | (n = 53) | |||
| 0 GAGC | 71.1% | 72.9% | 1.00 | 72.0% | 1.00 | 69.8% | 1.00 |
| 1 or 2 GAGC | 28.9% | 27.1% | 0.91 (0.48 to 1.75) | 28.0% | 0.96 (0.61 to 1.51) | 30.2% | 1.06 (0.55 to 2.05) |