Significant associations between single nucleotide polymorphisms and coronary heart disease or myocardial infarction uncovered in this population for the first time
| Gene (polymorphism) | Genotype | Random population | Coronary heart disease cases | Myocardial infarction cases | Coronary heart disease adjusted odds ratio (95% confidence interval) | p coronary heart disease | Myocardial infarction adjusted odds ratio (95% confidence interval) | p myocardial infarction |
|---|---|---|---|---|---|---|---|---|
| PAI2_1 and PAI2_2 are in complete linkage disequilibrium (D’ = 1.00) | ||||||||
| THBS4 (THBS4_1) | CC | 19 | 20 | 11 | 1.77 (0.85, 3.68) | 0.08 | 2.22 (0.93, 5.28) | 0.002 |
| CG | 121 | 126 | 79 | 1.42 (0.99, 2.03) | 2.07 (1.35, 3.17) | |||
| GG | 266 | 196 | 94 | 1.00 | 1.00 | |||
| THBS2 (THBS2_2) | GG | 38 | 15 | 6 | 0.51 (0.25, 1.05) | 0.03 | 0.38 (0.14, 1.01) | 0.02 |
| GT | 147 | 147 | 83 | 1.29 (0.90, 1.85) | 1.40 (0.92, 2.15) | |||
| TT | 199 | 155 | 80 | 1.00 | 1.00 | |||
| PAI2 (PAI2_1) | GG | 15 | 15 | 9 | 1.56 (0.67, 3.65) | 0.21 | 2.35 (0.90, 6.12) | 0.03 |
| GC | 146 | 139 | 85 | 1.32 (0.93, 1.88) | 1.64 (1.08, 2.49) | |||
| CC | 247 | 181 | 88 | 1.00 | 1.00 | |||
| PAI2 (PAI2_2)* | GG | 17 | 15 | 9 | 1.34 (0.59, 3.06) | 0.24 | 1.99 (0.78, 5.07) | 0.03 |
| GC | 141 | 135 | 83 | 1.34 (0.94, 1.91) | 1.69 (1.11, 2.56) | |||
| CC | 244 | 181 | 89 | 1.00 | 1.00 | |||