TDT analysis of the IL12B C1159A SNP in 337 Danish type I diabetes simplex families, and in 795 type I diabetes multiplex families (153 Danish, 184 Swedish, 77 Norwegian, 126 French, and 255 American)
| Affected offspring | Unaffected offspring | |||||
|---|---|---|---|---|---|---|
| Allele A, N (%T) | Allele C, N (%T) | p Value | Allele A, N (%T) | Allele C, N (%T) | p Value | |
| Allele transmission patterns from heterozygous parents to affected and unaffected offspring are shown; χ2 statistics were used and the corresponding p values are shown. | ||||||
| Danish simplex families | 99 (56) | 77 (44) | 0.10 | 109 (63) | 65 (37) | 0.0009 |
| Multiplex families | ||||||
| Danish | 63 (52) | 58 (48) | 0.65 | 27 (59) | 19 (41) | 0.24 |
| Swedish | 77 (50) | 76 (50) | 0.94 | 29 (42) | 40 (58) | 0.19 |
| Norwegian | 45 (47) | 51 (53) | 0.54 | 17 (45) | 21 (55) | 0.52 |
| French | 59 (47) | 66 (53) | 0.53 | 44 (48) | 47 (52) | 0.75 |
| American | 129 (44) | 162 (56) | 0.05 | 38 (51) | 36 (49) | 0.82 |
| All multiplex families | 373 (47) | 413 (53) | 0.15 | 155 (49) | 163 (51) | 0.65 |