Effect of age of onset on the association between single nucleotide polymorphisms (SNPs) or SNP haplotypes in the MDR1 gene and Parkinson’s disease
| ⩽55 years old | ⩾60 years old | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP/haplotype | Allele/haplotype | p Value | Freq control | Freq PD | OR | 95% CI | p Value | Freq control | Freq PD | OR | 95% CI |
| Data for the alleles of the 5 SNP are shown. Only relevant haplotypes that have significant CI values in either tables 2, 3, or 4 are shown. Values in bold are significant. | |||||||||||
| CI, confidence interval; freq, frequency; OR, odds ratio; PD, Parkinson’s disease. | |||||||||||
| i-1/-41(A/G) | A | 0.0100 | 58.000 | 108.000 | – | 0.8720 | 318.000 | 205.000 | – | ||
| G | 14.000 | 8.000 | 0.307 | 0.125 to 0.758 | 22.000 | 15.000 | 1.058 | 0.521 2.074 | |||
| e12/1236(C/T) | T | 0.9741 | 43 | 69 | – | 0.0608 | 226 | 129 | – | ||
| C | 29.000 | 47.000 | 0.992 | 0.550 to 1.806 | 114.000 | 91.000 | 1.334 | 0.950 to 1.896 | |||
| e21/2677(G/T/A) | T | 0.1299 | 27 | 40 | – | 0.0102 | 156 | 73 | – | ||
| A | 17.000 | 16 | 0.635 | 0.268 to 1.479 | 41.001 | 30.000 | 1.564 | 0.898 to 2.693 | |||
| G | 28.002 | 60.000 | 1.446 | 0.740 to 2.819 | 143.000 | 117.000 | 1.748 | 1.209 to 2.534 | |||
| e26/3435(C/T) | T | 0.9351 | 24 | 38 | – | 0.0061 | 144 | 68 | – | ||
| C | 48.000 | 78.000 | 1.0261 | 0.5531 to 1.9159 | 196.000 | 152.000 | 1.6421 | 1.1482 to 2.5341 | |||
| e28/4036(A/G) | A | 0.6112 | 49.0013 | 83 | – | 0.9778 | 250 | 162 | – | ||
| G | 23.000 | 33.000 | 0.847 | 0.443 to 1.622 | 90.000 | 58.000 | 0.995 | 0.676 to 1.453 | |||
| i-1/-41(A/G)-e12/1236(C/T) | A-T | 0.2503 | 36.2 | 66.3 | – | 0.0754 | 219.7 | 123.7 | – | ||
| A-C | 21.800 | 41.700 | 1.045 | 0.531 to 2.097 | 98.300 | 81.300 | 1.470 | 1.005 to 2.143 | |||
| e12/1236(C/T)-e21/2677(G/T/A) | T-T | 0.0489 | 27 | 37.2 | – | 0.0774 | 152.3 | 71.6 | – | ||
| T-G | 12.200 | 31.800 | 1.892 | 0.820 to 4.559 | 69.000 | 56.000 | 1.719 | 1.095 to 2.720 | |||
| C-A | 13.200 | 16.000 | 0.880 | 0.365 to 2.180 | 36.600 | 28.600 | 1.664 | 0.943 to 2.945 | |||
| C-G | 15.800 | 28.200 | 1.294 | 0.581 to 2.916 | 73.700 | 61.000 | 1.759 | 1.134 to 2.742 | |||
| e21/2677(G/T/A)-e26/3435(C/T) | T-T | 0.1575 | 21.8 | 37 | – | 0.0562 | 135.5 | 61.6 | – | ||
| G-C | 26.910 | 60.000 | 1.314 | 0.652 to 2.644 | 134.500 | 112.300 | 1.836 | 1.241 to 2.732 | |||
| e26/3435(C/T)-e28/4036(A/G) | T-A | 0.8473 | 16.59 | 30.7 | – | 0.0423 | 126.2 | 61.6 | – | ||
| C-A | 32.400 | 52.300 | 0.871 | 0.388 to 1.913 | 123.800 | 100.4 | 1.657 | 1.081 to 2.583 | |||
| C-G | 15.600 | 25.700 | 0.891 | 0.369 to 2.137 | 72.200 | 51.600 | 1.465 | 0.910 to 2.352 | |||
| i-1/-41(A/G)-e12/1236(C/T)-e21/2677(G/T/A) | A-T-T | 0.0954 | 23.1 | 36.1 | – | 0.4225 | 148.1 | 67.8 | – | ||
| A-T-G | 9.900 | 29.700 | 1.916 | 0.786 to 4.992 | 67.200 | 54.500 | 1.771 | 1.100 to 2.843 | |||
| A-C-A | 6.000 | 12.200 | 1.299 | 0.411 to 4.532 | 24.900 | 22.400 | 1.961 | 1.019 to 3.793 | |||
| A-C-G | 15.500 | 28.600 | 1.184 | 0.527 to 2.709 | 70.100 | 57.600 | 1.792 | 1.127 to 2.849 | |||
| e12/1236(C/T)-e21/2677(G/T/A)-e26/3435(C/T) | T-T-T | 0.2693 | 21.8 | 34.3 | – | 0.3340 | 134.2 | 61.7 | – | ||
| T-G-C | 12.500 | 31.600 | 1.611 | 0.686 to 3.919 | 69.1 | 56 | 1.765 | 1.069 to 2.820 | |||
| C-G-C | 14.400 | 28.400 | 1.248 | 0.536 to 2.936 | 65.200 | 56.200 | 1.872 | 1.177 to 3.078 | |||
| e21/2677(G/T/A)-e26/3435(C/T)-e28/4036(A/G) | T-T-A | 0.5064 | 14.7 | 30.6 | – | 0.0225 | 116.8 | 56.2 | – | ||
| G-C-A | 22.400 | 46.000 | 0.988 | 0.425 to 2.277 | 94.000 | 89.000 | 1.963 | 1.250 to 3.106 | |||
| G-C-G | 4.500 | 14.000 | 1.504 | 0.452 to 5.929 | 40.100 | 23.500 | 1.221 | 0.639 to 2.279 | |||
| i-1/-41(A/G)-e12/1236(C/T)-e21/2677(G/T/A)-e26/3435(C/T) | A-T-T-T | 0.6496 | 20.7 | 33.1 | – | 0.8822 | 130 | 57.6 | – | ||
| A-T-G-C | 9.800 | 29.600 | 2.017 | 0.717 to 5.255 | 66.400 | 50.200 | 1.704 | 1.045 to 2.976 | |||
| A-C-A-C | 6.200 | 11.105 | 1.185 | 0.361 to 4.063 | 25.600 | 20.400 | 1.979 | 1.013 to 3.873 | |||
| A-C-G-C | 14 | 28.7 | 1.4227 | 0.5391 to 3.4622 | 63.5 | 57.8 | 2.0584 | 1.1659 to 3.369 | |||
| e12/1236(C/T)-e21/2677(G/T/A)-e26/3435(C/T)-e28/4036(A/G) | T-T-T-A | 0.6580 | 15 | 29.3 | – | 0.4147 | 114.9 | 55.7 | – | ||
| T-G-C-A | 8.500 | 24.500 | 1.481 | 0.515 to 4.531 | 41.600 | 37.400 | 1.851 | 1.034 to 3.377 | |||
| T-G-C-G | 4.500 | 7.400 | 0.830 | 0.182 to 3.675 | 27.400 | 14.400 | 1.075 | 0.462 to 2.393 | |||
| C-G-C-A | 13.900 | 21.300 | 0.784 | 0.300 to 2.089 | 53.200 | 52.600 | 2.046 | 1.159 to 3.540 | |||
| C-G-C-G | 0.000 | 6.800 | 12.100 | 8.300 | |||||||
| i1/-41(A/G)-e12/1236(C/T)-e21/2677(G/T/A)-e26/3435(C/T) e28/4036(A/G) | A-T-T-T-A | 0.9934 | 15.9 | 28.5 | – | 0.9718 | 109.7 | 52.9 | – | ||
| A-T-G-C-A | 6.500 | 24.300 | 2.092 | 0.646 to 8.328 | 39.800 | 37.000 | 1.924 | 1.060 to 3.570 | |||
| A-T-G-C-G | 3.700 | 5.700 | 0.864 | 0.171 to 4.612 | 26.600 | 13.000 | 1.005 | 0.385 to 2.490 | |||
| A-C-A-C-G | 4.1 | 7.6 | 1.0229 | 0.2504 to 4.691 | 20.8 | 18.5 | 1.8464 | 0.8583 to 3.9307 | |||
| A-C-G-C-A | 14.100 | 20.000 | 0.783 | 0.300 to 2.540 | 53.500 | 49.000 | 1.901 | 1.017 to 3.527 | |||
| A-C-G-C-G | 0.000 | 7.900 | 10.900 | 8.300 | |||||||