Table 3

Effect of sex on the association of single nucleotide polymorphisms (SNPs) or haplotypes of SNPs in the MDR1 gene with Parkinson’s’ disease

		Female					Male
SNP/haplotype	Allele/haplotype	p Value	Freq control	Freq PD	OR	95% CI	p Value	Freq control	Freq PD	OR	95% CI
Data for the alleles of the five SNPs are shown. Only relevant haplotypes that have significant CI values in either tables 2, 3, or 4 are shown. Values in bold are significant.
CI, confidence interval; freq, frequency; OR, odds ratio; PD, Parkinson’s disease.
i-1/-41(A/G)	A	0.9668	196	179	–		0.6267	212	199	–
	G	0.9668	14	13	1.0167	0.4528 to 2.232	0.6267	26	21	0.86049	0.4639 to 1.5798
e12/1236(C/T)	T	0.1912	139	115	–		0.1021	153	125	–
	C	0.1912	71	77	1.310769	0.8756 to 1.9713	0.1021	85	95	1.36793	0.9351 to 1.9931
e21/2677(G/T/A)	T	0.1998	92	69	–		0.0015	108	65	–
	A		29	25	1.149345	0.6196 to 2.1281		33	33	1.66138	0.941 to 2.9528
	G		89	98	1.468101	0.9576 to 2.2536		97	122	2.08964	1.3957 to 3.1425
e26/3435(C/T)	T	0.1618	83	63	–		0.0009	100	60
	C	0.1618	127	129	1.338052	0.8938 to 2.0228	0.0009	138	160	1.9322	1.3057 to 2.8756
e28/4036(A/G)	A	0.1670	148	147	–		0.0600	182	151	–
	G	0.1670	62	45	0.730769	0.4624 to 1.1361	0.0600	56	69	1.485	0.9804 to 2.2449
i-1/-41(A/G)-e12/1236(C/T)	A-T	0.6001	133	109	–	–	0.3117	143	116	–	–
	A-C	0.6001	63	70	1.352262	0.8716 to 2.0865	0.3117	69	83	1.47178	0.9716 to 2.2364
e12/1236(C/T)-e21/2677(G/T/A)	T-T	0.5543	91	68	–		0.0008	105	62	–
	T-G		46	46	1.356151	0.7999 to 2.2938		41	63	2.59005	1.553 to 4.3758
	C-A		26	24	1.212953	0.6349 to 2.3216		27	33	2.0926	1.1362 to 3.8989
	C-G		43	52	1.600788	0.9567 to 2.6824		56	59	1.80188	1.105 to 2.935
e21/2677(G/T/A)-e26/3435(C/T)	T-T	0.6236	78	59	–		0.0029	95	57	–
	G-C	0.6236	84	94	1.480759	0.9428 to 2.3309	0.0029	93	122	2.17695	1.42 to 3.3418
e26/3435(C/T)-e28/4036(A/G)	T-A	0.1622	71	55	–		0.0052	86	52	–
	C-A		77	92	1.54442	0.935 to 2.5759		96	99	1.69206	1.0509 to 2.756
	C-G		50	37	0.954989	0.5446 to 1.6637		42	61	2.39309	1.4302 to 4.0662
i-1/-41(A/G)-e12/1236(C/T)-e21/2677(G/T/A)	A-T-T	0.7510	87	63	–	0.5446 to 1.6637		0.0175	97	57	–
	A-T-G		43	45	1.436822	0.8363 to 2.4752	39		59	2.59609	1.5161 to 4.4975
	A-C-A		19	21	1.488114	0.7266 to 3.0982	14		23	2.85191	1.3312 to 6.422
	A-C-G		43	48	1.522141	0.8978 to 2.5983	55		59	1.85694	1.1243 to 3.0972
e12/1236(C/T)-e21/2677(G/T/A)-e26/3435(C/T)	T-T-T	0.7280	78	58	–		0.0038	93	55	–
	T-G-C		45	42	1.240787	0.727 to 2.1228		42	63	2.54487	1.5209 to 4.3241
	C-G-C		38	52	1.835104	1.0824 to 3.1754		51	59	1.95541	1.1839 to 3.2614
e21/2677(G/T/A)-e26/3435(C/T)-e28/4036(A/G)	T-T-A	0.2079	64	52	–		0.0047	81	50	–
	G-C-A		56	80	1.739484	1.0123 to 2.9961		77	88	1.84233	1.1298 to 3.0296
	G-C-G		28	14	0.611446	0.2579 to 1.3278		17	34	3.64414	1.6523 to 7.2689
i-1/-41(A/G)-e12/1236(C/T)-e21/2677(G/T/A)-e26/3435(C/T)	A-T-T-T	0.9632	75	53	–		0.1612	86	50	–
	A-T-G-C		43	40	1.341026	0.7595 to 2.4776		39	59	2.6128	1.4849 to 4.5873
	A-C-A-C		19	21	1.511609	0.7262 to 3.1824		14	22	2.6491	1.2262 to 5.9862
	A-C-G-C		38	48	1.795518	0.9749 to 3.1911		50	59	2.0291	1.2127 to 3.4638
e12/1236(C/T)-e21/2677(G/T/A)-e26/3435(C/T)-e28/4036(A/G)	T-T-T-A	0.7215	64	51	–		0.0188	78	51	–
	T-G-C-A		25.2	35	1.7483	0.8809 to 3.5168		29.4	41.5	2.18	1.1666 to 4.1128
	T-G-C-G		20.4	6.6	0.4092	0.0767 to 1.1701		12.6	22.2	2.7151	1.1824 to 6.8876
	C-G-C-A		30.4	44.7	1.8451	0.9874 to 3.5098		47.4	45.9	1.493	0.8456 to 2.6651
	C-G-C-G		7.6	7.2	1.1821	0.2401 to 4.6633		3.3	12.4	5.7776	1.2864 to 93.8129
i-1/-41(A/G)-e12/1236(C/T)-e21/2677(G/T/A)-e26/3435(C/T)-e28/4036(A/G)	A-T-T-T-A	0.9839	62.2	47.9	–		0.6324	73.5	44.1	–
	A-T-G-C-A		25.2	37	1.90872	0.9618 to 3.944		26	38.1	2.4498	1.2536 to 4.8135
	A-T-G-C-G		17.5	2.4	0.1801	0.0037 to 1.0173		12.5	21	2.8043	1.09 to 7.1264
	A-C-A-C-G		13.6	17	1.6276	0.7056 to 3.897		11.2	16.7	2.4791	1.0362 to 6.2267
	A-C-G-C-A		31.2	38.3	1.5909	0.7891 to 3.1378		47.8	47.4	1.6576	0.913 to 3.0238
	A-C-G-C-G		7.5	9.3	1.6211	0.3125 to 6.898		3.1	12.8	6.9369	1.5434 to 114.829