Table 1

Linkage analysis of MPS IIIC and markers in the chromosome 8 candidate interval

Order	Locus	Marker	Genetic location (cM)*	Homozygosity†		Maximum lod score	θ
Order	Locus	Marker	Genetic location (cM)*	Patients	Controls	Maximum lod score	θ
*Kosambi scale, see text for details. According to the UCSC Genome Browser (July 2003 assembly), the centromere is located between markers 2 and 3. †Homozygosity was estimated as the proportion of homozygous genotypes observed. Because of a few missing data, the sample sizes ranged from 30 to 33 patients and 37 to 38 controls. See text for description of the subset of 33 patients.
1	D8S532	AFM081yd11	59.76	0.48	0.16	4.74	0.032
2	D8S268	AFM156xa3	60.01	0.67	0.43	3.93	0.028
3	D8S1051	UT7847	60.92	0.58	0.42	4.16	0.000
4	D8S1460	ATA38C03	61.85	0.64	0.32	5.56	0.000
5	D8S519	AFM234vh8	62.08	0.48	0.21	7.25	0.000
6	D8S531	AFM081xe9	62.26	0.79	0.45	4.19	0.000
7	D8S1745	AFM200xh12	62.89	0.48	0.18	5.77	0.000
8	D8S589	GATA12H01	62.89	0.52	0.37	4.87	0.000
9	D8S1831	AFMa071yf9	63.65	0.45	0.45	6.45	0.000
10	D8S538	AFM274ve5	63.89	0.43	0.32	5.68	0.000
11	D8S517	AFM224xh6	64.48	0.91	0.81	1.49	0.000
12	D8S524	AFM242zf6	64.48	0.58	0.47	3.83	0.000
13	D8S1815	AFMa046wg9	64.73	0.73	0.26	5.48	0.000
14	D8S1110	GATA8G10	65.47	0.56	0.21	7.02	0.000
15	D8S601	AFM276xe9	65.75	0.44	0.27	7.05	0.000
16	D8S509	AFM203zc1	67.47	0.72	0.45	4.51	0.000
17	D8S2332	GATA156H01	68.19	0.58	0.47	6.46	0.000
18	D8S285	AFM255yb9	68.31	0.48	0.11	2.31	0.090
19	D8S1816	AFM021te1	68.63	0.70	0.68	2.57	0.000
20	D8S166	Mfd159A	68.92	0.30	0.22	4.60	0.018