Phenotypic, genetic and environmental correlations between quantitative plasma phenotype and thrombotic liability
| Phenotype | ρp (p value) | ρg (p value) | ρe (p value) |
|---|---|---|---|
| P values for ρ≠0 are shown in parenthesis; ns, non-significant (p>0.1); ρp, phenotypic correlation; ρg, genetic correlation; ρe, environmental correlation; †The 95% confidence interval of the genetic correlation between C4BPβ+ and thrombosis is (0.55–1). ‡Data extracted from Souto et al,6 showing the four phenotypes with the highest phenotypic and genetic correlations with thrombosis from a panel of 40 haemostasis related phenotypes. §Thromboplastin thrombomodulin mediated time20. APCR, Activated Protein C Resistance; FVIII, Factor VIII; t-PA, tissue plasminogen activator; vWF, von Willebrand Factor. | |||
| Total C4BP | 0.18 (0.07) | 0.54 (0.02) | −0.13 (ns) |
| C4BPβ+ | 0.27 (0.03) | 1.00 (<<0.0001)† | −0.27 (0.09) |
| Total PS | 0.12 (ns) | 0.26 (ns) | −0.02 (ns) |
| Free PS | 0.07 (ns) | 0.35 (0.07) | −0.29 (ns) |
| Functional PS | −0.18 (ns) | −0.09 (ns) | −0.30 (ns) |
| APCR‡ | −0.23 (0.0003) | −0. 65 (<<0.0001) | 0.66 (<<0.0001) |
| FVIII‡ | 0.28 (0.0002) | 0.68 (0.0005) | −0.12 (ns) |
| t-PA‡ | 0.18 (0.0002) | 0.75 (0.007) | −0.10 (ns) |
| vWF‡ | 0.26 (0.0001) | 0.72 (0.0005) | −0.18 (ns) |
| R1§ | −0.31 (0.0006) | −1.00 (<<0.0001) | 0.38 (0.06) |