Gene | Number of families | Number of mutations | IC model | Brcapro model | ||||
---|---|---|---|---|---|---|---|---|
Mutations expected | χ2 | Log likelihood | Mutations expected | χ2 | Log likelihood | |||
BRCA1 and BRCA2 | ||||||||
HBC | 357 | 60 | 62.7 | 0.14 | −204.2 | 59.3 | 0.01 | −204.8 |
HBOC | 151 | 57 | 47.7 | 2.63 | −138.8 | 41.2 | 8.31 | −149.5 |
HOC | 31 | 8 | 6.7 | 0.31 | −16.1 | 4.0 | 4.70 | −15.7 |
MBC | 29 | 8 | 10.7 | 1.12 | −22.7 | 11.6 | 1.83 | −26.2 |
Total | 568 | 133 | 127.9 | 4.20 | −381.7 | 116.0 | 14.84 | −396.2 |
BRCA1 | ||||||||
HBC | 357 | 27 | 49.0 | 11.4 | −97.2 | 47.4 | 10.1 | −94.3 |
HBOC | 151 | 45 | 41.2 | 0.5 | −102.7 | 35.8 | 3.1 | −110.4 |
HOC | 31 | 7 | 6.3 | 0.1 | −13.2 | 3.7 | 3.3 | −13.4 |
MBC | 21 | 1 | 3.4 | 2.0 | −6.6 | 3.5 | 2.2 | −8.6 |
Total | 560 | 80 | 99.9 | 14.1 | −219.6 | 90.5 | 18.8 | −226.7 |
BRCA2 | ||||||||
HBC | 276 | 33 | 13.7 | 28.7 | −117.4 | 11.8 | 39.5 | −121.4 |
HBOC | 131 | 12 | 6.6 | 4.7 | −43.1 | 5.4 | 8.3 | −45.6 |
HOC | 28 | 1 | 0.4 | 1.1 | −3.9 | 0.3 | 2.0 | −2.9 |
MBC | 29 | 7 | 5.8 | 0.3 | −18.1 | 5.9 | 0.2 | −19.0 |
Total | 464 | 53 | 26.4 | 34.8 | −182.5 | 23.5 | 50.0 | −188.9 |