Table 1

Distribution of families by proband age and cancer type

Pedigree characteristics				Family history of cancer						Mutation found
Proband		Number of families	Number of relatives	Breast	Ovarian	Bilateral breast	Breast and ovarian	Male breast cancer	Mean affected members*	*BRCA1*	*BRCA2*
Cancer	Age (years)	Number of families	Number of relatives	Breast	Ovarian	Bilateral breast	Breast and ovarian	Male breast cancer	Mean affected members*	*BRCA1*	*BRCA2*
*Average number of members per family (probands included) affected by one or more breast or ovarian cancers.
Breast	<40	132	1351	129	17	17	10	5	2.35	26	12
	40–55	143	1998	241	19	25	5	7	3.08	6	12
	>55	64	1010	127	9	13	3	2	3.41	4	5
Bilateral breast		71	890	90	7	20	2	0	2.68	6	10
Ovary	<50	40	469	28	31	1	3	0	2.58	14	0
Ovary	⩾50	39	582	45	24	3	2	1	2.92	11	5
Breast and ovarian		49	609	38	10	3	1	1	2.08	12	4
Male breast		15	241	27	3	1	0	0	3.07	0	5
Unaffected		15	134	24	2	3	1	0	2.00	1	0
Total		568	7284	749	122	86	27	16	2.68	80	53