Interleukin 10 −1082G→A genotype frequencies in men with acute myocardial infarction, age matched controls, and oldest old controls from north and south Italy. Values are numbers (percentages)
| Participants | No of participants | Genotype | ||
|---|---|---|---|---|
| GG | GA | AA | ||
| The genotype percentages were obtained considering the following haplotype combinations: (A) −1082G/−819C/−592C homozygous participants for −1082GG genotype; (B) −1082A/−819C/−592C −1082G/−819C/−592C and −1082A/−819T/−592A −1082G/−819C/−592C heterozygous participants for −1082GA genotypes; (C) −1082A/−819C/−592C and −1082A/−819T/−592A homozygous and −1082A/−819C/−592C −1082A/−819T/−592A heterozygous participants for −1082AA genotypes. For the comparison of genotype distribution, χ2 test with Yates’ correction was performed (Graphpad Instat, Graphpad Software, San Diego, CA, USA). Bonferroni’s correction was applied by multiplying the obtained p values by three possible haplotypes. | ||||
| *p = 0.0003 (vs. male controls); †p = 0.0003 (vs. oldest old men); ‡p = 0.0024 (vs. oldest old men); §p = 0.0069 (vs. male controls); ¶p = 0.0003 (vs. oldest old men); **p = 0.019 (vs. oldest old men). | ||||
| North Italy | ||||
| “Old” patients with acute myocardial infarction | 142*† | 30 (21.1) | 52 (36.6) | 60 (42.2) |
| Male controls | 153‡ | 48 (31.4) | 75 (49.0) | 30 (19.6) |
| Oldest old men | 57 | 34 (59.6) | 18 (31.6) | 5 (8.8) |
| South Italy | ||||
| “Young” patients with acute myocardial infarction | 90**†† | 17 (18.9) | 29 (32.2) | 44 (48.9) |
| Male controls | 110‡ | 26 (23.6) | 56 (50.9) | 28 (25.5) |
| Oldest old men | 52 | 25 (48.1) | 23 (44.2) | 6 (11.5) |