OFBCR criteria for defining probands (all affected with invasive breast cancer) at possible increased genetic risk of breast cancer
| Criteria | Description |
|---|---|
| 1 | At least 1 first degree relative with breast or ovarian cancer |
| 2 | At least 2 second degree relatives with breast or ovarian cancer |
| 3 | Proband diagnosed with breast cancer at age ⩽35 |
| 4 | At least 1 second or 1 third degree relative with breast cancer at age ⩽35 or ovarian cancer at age ⩽60 |
| 5 | Proband is male |
| 6 | At least 1 second or 1 third degree relative with male breast cancer |
| 7 | Proband diagnosed with both breast and ovarian cancer or multiple breast primaries |
| 8 | At least 1 second or 1 third degree relative with breast and ovarian cancer |
| 9 | At least 1 second or 1 third degree relative with multiple breast cancer primaries |
| 10 | Family has at least three relatives in a first degree relationship with any combination of breast, ovarian, colon, prostate, or pancreatic cancer or sarcoma with at least 1 diagnosis ⩽50 |
| 11 | Proband is Ashkenazi Jewish |