Subjects affected with breast and/or ovarian cancer with a family history of breast cancer who were analysed for mutations in p16INK4a and p14ARF by SSCP and sequencing analyses. Cancers reported in the proband, and relatives with breast or ovarian cancer, are indicated, together with age at diagnosis
| Family No | Cancer in proband (age at diagnosis) | Degree relatives with breast or ovarian cancer |
|---|---|---|
| OV=ovarian carcinoma, Sarc=sarcoma, Panc=pancreatic carcinoma, Mel=melanoma, Thy=thyroid, Ut=uterus. | ||
| 543 | Breast (38), Mel (43), Neurofibroma | Breast I (26 bilateral sib) Breast II (42), II (38), II (49) |
| 681 | Breast (49) | Breast I (42) |
| 766 | Breast (55), Mel (71) | Breast I (63) |
| 274 | Breast (39) | Breast I (49) Ov I (49) Ov II (58) |
| GT112 | Breast,(48) Thy (42) | Breast I (45) |
| 25 | Breast (48) | Breast I (41), II (81) |
| JW82 | Breast (37) | Breast I (38) |
| 1702 | Breast (50) | Breast I (40, 45 bilateral), III (40) |
| 1661 | Breast (40), B cell (unknown) | Breast I (72), II (30) |
| 909 | Breast (58) | Breast I (70), III (39), III (55) |
| 812 | Breast (47) | Breast I (54, 60 bilateral) |
| 560 | Breast (31) | Breast I (41), II (56) |
| 739 | Breast (43) | Breast I (45) |
| 566 | Breast (35, 42) Ov (53) | Breast I (52) |
| 24 | Breast (40,51) | Breast I (42), I (52, 78 bilateral), Breast II (80), II (47, 52 bilateral) |
| 18 | Breast (43) | Breast I (55), II (unknown) |
| 12 | Breast (45) | Breast I (45), II (61), II (60) |
| 445 | Breast (40) | Breast I,(45) (maternal side) Breast II (42), II (50)(paternal side) |
| 621 | Breast (42) | Breast I (45), I (34), I (44), I (35) |
| 1086 | Breast (49), Panc (55) | Breast I (53), I (68), III (34) |
| 2208 | Breast (40), Sarc (11) | Breast I (45) |
| 840 | Breast (36) | Breast I (66, 68 bilateral) |
| 412 | Breast (58,65) | Breast I (unknown) |
| 735 | Breast (43) | Breast I (30), II (65) |
| 330 | Breast (43) | Breast I (71), II (62) |
| 790 | Breast (52, 66) | Breast I (56), I (42), I (69) Ov I ((58) |
| 1277 | Breast (52), Mel (50), Ut (41) | Breast II (49) |
| GT30 | Breast (46) | Breast II (63), 4x IV (60, 63, 65, 65) Ov I (39) |
| JW87 | Breast (46) Lung (47) | Breast I (81), maternal side) Breast II (49) paternal side |
| JW53 | Breast (42 bilateral), Mel (55) | Breast II (67) (maternal side) Breast II (70), III (60) (paternal side) |
| 1184 | Ov (40), Ut (40) | Breast I (64) II (50), II (60), Ov I (47) Ov I (40) |