MC1R genotype in patients with melanoma and in control subjects; association of MC1R variants with the risk (odds ratios) of MM
| MC1R genotype | Patients (n = 108) | Controls (n = 105) | p | Odds ratios |
|---|---|---|---|---|
| n,number. | ||||
| Wt represents the wild type allele; V represents variant alleles. | ||||
| Odds ratios (indicated with 95% confidence intervals) compare Wt/V (heterozygotes) and V/V (two functional variants) with Wt/Wt. | ||||
| Wt/Wt | 31.5 (34) | 68.6 (72) | – | Reference |
| Wt/V | 52.8 (57) | 26.7 (28) | <.0001 | 4.3 (2.34–7.93) |
| V/V | 14.8 (16) | 4.7 (5) | <.0002 | 6.78 (2.29–20.03) |