Estimated haplotype frequencies of the −511C/T/intron 2 VNTR polymorphisms in patients with schizophrenia, patients with bipolar disorder (BP) with a positive family history (FH+), and the control group
| Diagnosis | n | Haplotype frequency (%) | ||||
|---|---|---|---|---|---|---|
| −511(1)-VNTR(A1) | −511(2)-VNTR(A2) | −511(2)-VNTR(A1) | −511(1)-VNTR(A2) | Others | ||
| FH+: patients with, at least, a first degree relative suffering from schizophrenia, bipolar disorder, or severe major depression. | ||||||
| For all comparisons, the haplotypes containing A3, A4, or A5 alleles of the IL-1RN VNTR were considered as a single haplotypic combination. | ||||||
| Schizophrenia v controls: haplotype distribution: χ2 = 12.70, P = 0.012. | ||||||
| Bipolar disorder v controls: haplotype distribution: χ2 = 9.81, P = 0.043. | ||||||
| Bipolar disorder FH+ v controls: haplotype distribution: χ2 = 15.90, P = 0.0031. | ||||||
| Schizophrenia v controls: haplotype (−511(1)-VNTR (A2)) v other haplotypes: χ2 = 9.99, P = 0.0015; OR = 2.49 (95% CI: 1.33 to 4.64). | ||||||
| Bipolar disorder v controls: haplotype (−511(1)-VNTR (A2)) v other haplotypes: χ2 = 8.09, P = 0.004; OR = 2.26 (95% CI: 1.22 to 4.17). | ||||||
| Bipolar disorder FH+ v controls: haplotype (−511(1)-VNTR (A2)) v other haplotypes: χ2 = 15.41, P = 0.00009; OR = 3.18 (95% CI: 1.66 to 6.05). | ||||||
| Schizophrenia | 78 | 81 (51.8%) | 17 (10.8%) | 27 (17.4%) | 26 (16.7%) | 5 (3.3%) |
| Bipolar disorder (BP) | 88 | 85 (48.1%) | 30 (16.8%) | 26 (15.0%) | 27 (15.5%) | 8 (4.6%) |
| BP FH+ | 59 | 52 (44.1%) | 17 (14.5%) | 20 (16.9%) | 24 (20.3%) | 5 (4.2%) |
| Controls | 175 | 179 (51.3%) | 62 (17.8%) | 71 (20.2%) | 26 (7.3%) | 12 (3.4%) |