Genotype and allele frequencies of the intron 2 VNTR polymorphism in patients with schizophrenia, patients with bipolar disorder (BP) with a positive family history (FH+), and the control group
| Diagnosis | n | Genotype frequency (%) | Allele frequency (%) | |||||
|---|---|---|---|---|---|---|---|---|
| A1/A1 | A1/A2 | A2/A2 | Others | A1 | A2 | A3, A4, A5 | ||
| FH+: patients with, at least, a first degree relative suffering from schizophrenia, bipolar disorder, or severe major depression. | ||||||||
| For all comparisons, A3, A4, and A5 were considered a single allele, and genotypes containing the A3, A4, or A5 allele were considered a single genotype. | ||||||||
| Schizophrenia v controls: allele: χ2 = 0.33, P = 0.84; genotype: χ2 = 1.62, P = 0.65. | ||||||||
| Bipolar disorder v controls: allele: χ2 = 3.81, P = 0.15; genotype: χ2 = 3.63; P = 0.30. | ||||||||
| Bipolar disorder FH+ v controls: allele: χ2 = 4.50, P = 0.105; genotype: χ2 = 4.08; P = 0.253. | ||||||||
| Schizophrenia | 78 | 35 (44.9%) | 34 (43.6%) | 4 (5.1%) | 5 (6.4%) | 108 (69.2%) | 43 (27.6%) | 5 (3.2%) |
| Bipolar disorder (BP) | 88 | 36 (40.9%) | 35 (39.8%) | 9 (10.2%) | 8 (9.1%) | 111 (63.1%) | 57 (32.4%) | 8 (4.5%) |
| BP FH+ | 59 | 22 (37.3%) | 26 (44.1%) | 6 (10.2%) | 5 (8.4%) | 72 (61.0%) | 41 (34.7%) | 5 (4.3%) |
| Controls | 175 | 91 (52.0%) | 62 (35.4%) | 11 (6.3%) | 11 (6.3%) | 250 (71.4%) | 88 (25.1%) | 12 (3.5%) |