Genotype and allele frequencies of the −511C/T polymorphism in patients with schizophrenia, patients with bipolar disorder (BP) and a positive family history (FH+), and the control group
| Diagnosis | n | Genotype frequency (%) | Allele frequency (%) | |||
|---|---|---|---|---|---|---|
| 1.1 | 1.2 | 2.2 | 1 | 2 | ||
| FH+: patients with at least a first degree relative suffering from schizophrenia, bipolar disorder, or severe major depression. | ||||||
| Schizophrenia v controls: allele: χ2 = 3.79, P = 0.051; OR = 1.50 (95% CI: 0.98 to 2.31); genotype: χ2 = 4.26, P = 0.119. | ||||||
| Bipolar disorder v controls: allele: χ2 = 1.48, P = 0.223; OR = 1.27 (95% CI: 0.85 to 1.90); genotype: χ2 = 2.89; P = 0.235. | ||||||
| Bipolar disorder FH+ v controls: allele: χ2 = 1.58, P = 0.208; OR = 1.33 (95% CI: 0.84 to 2.14); genotype: χ2 = 1.79; P = 0.408. | ||||||
| Schizophrenia | 78 | 39 (50.0%) | 33 (42.3%) | 6 (7.7%) | 111 (71.2%) | 45 (28.8%) |
| Bipolar disorder (BP) | 88 | 38 (43.2%) | 43 (48.8%) | 7 (8.0%) | 119 (67.6%) | 57 (32.4%) |
| BP FH+ | 59 | 27 (45.8%) | 27 (45.8%) | 5 (8.5%) | 81 (68.6%) | 37 (31.4%) |
| Controls | 176 | 69 (39.2%) | 81 (46.0%) | 26 (14.8%) | 219 (62.2%) | 133 (37.8%) |