Table 1

Characteristics of cleft palate patients screened for TBX22 mutations

Origin of patient	Male	Female	Family history		Syndromic*	CPO	CP+A
Origin of patient	Male	Female	+ve	−ve	Syndromic*	CPO	CP+A
*Includes putative Pierre-Robin syndrome (12), Stickler syndrome, chromosomal anomalies, Goldenhar-, and campomelic dysplasia-like syndromes; †includes CP only probands with first degree relative with ankyloglossia as part of their phenotype; ‡includes two pedigrees with male to male transmission; §includes four pedigrees with male to male transmission
USA	40	65	28	77	11	102	3†
Brazil	57	45	27‡	75	0	64	38†
Philippines	16	33	20§	29	7	49	0
Total	113	143	75	181	18	215	41