Genotype by smoking status | Controls, n (%) | Cases, n (%) | Model 1, OR (95% CI)* | Model 2, OR (95% CI)† |
---|---|---|---|---|
*Adjusted for age, sex, and area of residence. | ||||
†Adjusted for age, sex, area of residence, waist to hip ratio, income, physical activity, and history of diabetes and hypertension. | ||||
‡CYP1A1 and smoking interaction: p = 0.17. | ||||
§CYP1A2 and smoking interaction: p = 0.24. | ||||
CYP1A1‡ | ||||
Never+past smokers | ||||
*1A/*1A | 342 (48) | 251 (49) | 1.00 | 1.00 |
*1A/*2A | 287 (40) | 206 (41) | 0.98 (0.77 to 1.25) | 1.00 (0.77 to 1.29) |
*2A/*2A | 83 (12) | 51 (10) | 0.85 (0.58 to 1.26) | 0.89 (0.59 to 1.33) |
1–9 cigarettes/day | ||||
*1A/*1A | 46 (47) | 44 (49) | 1.00 | 1.00 |
*1A/*2A | 41 (42) | 40 (44) | 0.98 (0.53 to 1.81) | 1.02 (0.52 to 2.01) |
*2A/*2A | 11 (11) | 6 (7) | 0.61 (0.20 to 1.82) | 0.69 (0.20 to 2.38) |
⩾10 cigarettes/day | ||||
*1A/*1A | 56 (46) | 131 (48) | 1.00 | 1.00 |
*1A/*2A | 54 (44) | 108 (39) | 0.84 (0.53 to 1.33) | 0.81 (0.50 to 1.31) |
*2A/*2A | 12 (10) | 36 (13) | 1.38 (0.66 to 2.89) | 1.32 (0.61 to 2.85) |
CYP1A2§ | ||||
Never+past smokers | ||||
*1A/*1A | 352 (49) | 225 (44) | 1.00 | 1.00 |
*1A/*1F | 289 (41) | 218 (43) | 1.17 (0.91 to 1.49) | 1.23 (0.95 to 1.59) |
*1F/*1F | 71 (10) | 65 (13) | 1.43 (0.98 to 2.09) | 1.44 (0.97 to 2.13) |
1–9 cigarettes/day | ||||
*1A/*1A | 50 (51) | 38 (42) | 1.00 | 1.00 |
*1A/*1F | 41 (42) | 39 (43) | 1.27 (0.68 to 2.37) | 1.15 (0.58 to 2.27) |
*1F/*1F | 7 (7) | 13 (15) | 2.41 (0.86 to 6.74) | 2.08 (0.66 to 6.52) |
⩾10 cigarettes/day | ||||
*1A/*1A | 59 (48) | 122 (44) | 1.00 | 1.00 |
*1A/*1F | 57 (47) | 127 (46) | 1.08 (0.69 to 1.70) | 1.07 (0.67 to 1.71) |
*1F/*1F | 6 (5) | 26 (10) | 2.05 (0.79 to 5.31) | 1.93 (0.72 to 5.16) |