CYP1A1 and CYP1A2 genotypes and risk of MI
| Genotype | Controls, n (%) | Cases, n (%) | Model 1, OR (95% CI)† | Model 2, OR (95% CI)‡ |
|---|---|---|---|---|
| †Adjusted for age, sex, and area of residence. | ||||
| ‡Adjusted for age, sex, area of residence, smoking status, waist to hip ratio, income, physical activity, and history of diabetes and hypertension. | ||||
| *p<0.05. | ||||
| CYP1A1 | ||||
| *1A/*1A | 444 (48) | 426 (49) | 1.00 | 1.00 |
| *1A/*2A | 382 (41) | 354 (40) | 0.97 (0.80 to 1.18) | 0.96 (0.78 to 1.19) |
| *2A/*2A | 106 (11) | 93 (11) | 0.91 (0.67 to 1.25) | 0.92 (0.66 to 1.28) |
| CYP1A2 | ||||
| *1A/*1A | 461 (49) | 385 (44) | 1.00 | 1.00 |
| *1A/*1F | 387 (42) | 384 (44) | 1.19 (0.98 to 1.44) | 1.19 (0.97 to 1.47) |
| *1F/*1F | 84 (9) | 104 (12) | 1.48 (1.07 to 2.03) | 1.55 (1.10 to 2.18)* |