Clinical characteristics of the patients and their comparison by each genotype in women and men
| Women (n=143) | Men (n=128) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Genotype of CYP11B2 | Genotype of CYP11B2 | ||||||||
| Total n=271 | TT n=64 | CT n=63 | CC n=16 | P value | TT n=52 | CT n=64 | CC n=12 | P value | |
| ACEI/ARB, angiotensin-I converting enzyme inhibitor and/or angiotensin receptor blocker; NS, not statistically significant. Values are mean (SD). | |||||||||
| At the time of renal biopsy | |||||||||
| Age (year) | 37.0 (13.4) | 38.9 (13.4) | 36.0 (13.0) | 35.6 (14.0) | NS | 38.4 (12.4) | 34.4 (14.3) | 41.0 (12.7) | NS |
| Urinary protein excretion (g/day) | 1.36 (1.35) | 1.17 (1.20) | 1.02 (1.17) | 1.63 (1.39) | NS | 1.62 (1.71) | 1.56 (1.30) | 1.53 (0.98) | NS |
| Serum creatinine (mg/dl) | 0.99 (0.62) | 0.84 (0.32) | 0.77 (0.26) | 0.91 (0.52) | NS | 1.24 (0.75) | 1.16 (0.87) | 1.14 (0.27) | NS |
| Creatinine clearance (ml/min) | 89.2 (33.1) | 83.2 (25.6) | 96.6 (33.5) | 82.9 (33.4) | NS | 88.2 (33.4) | 92.0 (39.7) | 82.5 (24.6) | NS |
| Blood pressure (mm Hg) | NS | NS | |||||||
| Systolic | 127.6 (18.3) | 126.6 (18.7) | 123.6 (17.4) | 130.8 (25.9) | NS | 130.1 (16.0) | 128.4 (18.1) | 133.4 (19.5) | NS |
| Diastolic | 77.1 (13.5) | 76.4 (12.1) | 74.8 (12.2) | 76.9 (15.4) | NS | 77.9 (15.0) | 77.9 (14.4) | 84.5 (13.2) | NS |
| Incidence of hypertension (%) | 36.4 | 39.1 | 22.0 | 35.7 | NS | 41.2 | 37.5 | 66.7 | NS |
| During observation | |||||||||
| Observed period (month) | 92.0 (66.8) | 102.1 (61.9) | 86.9 (58.3) | 61.1 (40.1) | 0.0366 | 91.7 (80.6) | 92.7 (74.1) | 105.7 (48.3) | NS |
| Incidence of progressive renal disease (%) | 31.0 | 29.0 | 25.8 | 50.0 | NS | 29.4 | 34.4 | 41.7 | NS |
| Corticosteroid (%) | 28.3 | 27.1 | 23.2 | 33.3 | NS | 32.7 | 28.3 | 33.3 | NS |
| ACEI/ARB (%) | 40.8 | 41.3 | 33.9 | 50.0 | NS | 54.9 | 33.3 | 41.7 | NS |
| Blood pressure (mm Hg) | |||||||||
| Systolic | 128.3 (16.7) | 128.1 (17.3) | 125.6 (17.8) | 133.1 (22.7) | NS | 127.6 (12.6) | 129.5 (16.4) | 132.8 (17.0) | NS |
| Diastolic | 77.4 (11.9) | 76.8 (10.5) | 75.9 (12.2) | 78.9 (13.1) | NS | 76.4 (11.6) | 78.3 (12.7) | 84.6 (11.7) | NS |