Family histories of patients with (n = 34) and without (n = 102) the CHEK2*1100delC mutation
| CHEK2 mutation present (n = 34) | CHEK2 mutation absent (n = 102) | Difference | |
|---|---|---|---|
| Any breast or ovarian cancer in | 19 (56%) | 37 (36%) | χ2 = 4.05 |
| first or second degree relative | p = 0.04 | ||
| Female breast cancer in | 7 (21%) | 15 (15%) | χ2 = 0.65 |
| first degree relative | p = 0.42 | ||
| Female breast cancer in first | 19 (56%) | 35 (34%) | χ2 = 4.96 |
| or second degree relative | p = 0.03 | ||
| Number of female breast cancer cases | |||
| 0 | 15 (44%) | 67 (66%) | |
| 1 | 13 (38%) | 25 (24%) | χ2 = 5.02 |
| 2 or more | 6 (18%) | 10 (10%) | p = 0.08 |
| Female breast cancer in | 9 (26%) | 21 (21%) | χ2 = 0.51 |
| first or second degree relative under age 60 | p = 0.47 | ||
| Female breast cancer in | 6 (17%) | 16 (15%) | χ2 = 0.07 |
| first or second degree relative under age 50 | p = 0.79 | ||
| Female breast cancer in | 2 (6%) | 9 (9%) | χ2 = 0.30 |
| first or second degree relative under age 40 | p = 0.59 | ||
| Female breast cancer in | 0 (0%) | 3 (3%) | χ2 = 1.02 |
| first or second degree relative under age 30 | p = 0.31 | ||
| Male breast cancer in first | 0 (0%) | 0 (0%) | |
| or second degree relative | – | ||
| Ovary cancer in first or | 1 (3%) | 5 (5%) | χ2 = 0.23 |
| second degree relative | p = 0.63 | ||
| Ovary and breast cancer in one | 0 (0%) | 2 (1.5%) | χ2 = 0.68 |
| first or second degree relative | p = 0.41 |