Allele and genotype frequencies for the G to T transversion at position −1359 in the promoter region of the CD14 gene
| Coeliac patients | |||
|---|---|---|---|
| Base | HLA-DQ2 or DQ-8 n=115) | Neither HLA-DQ2 nor DQ-8 (n= 37) | Healthy controls (n=180) |
| *Allelic frequency (Fisher’s exact test): typical v atypical HLA coeliac patients: p=0.631; typical HLA coeliac patients v healthy controls: p=0.251; atypical HLA coeliac patients v healthy controls: p=0.172. | |||
| §Genotype frequency (3×2 contingency tables): typical HLA coeliac patients v atypical HLA coeliac patients: χ2=2.680, p=0.262; typical HLA coeliac patients v healthy controls: χ2=4.19, p=0.123; atypical HLA coeliac patients v healthy controls: χ2=12.640, p=0.0018. | |||
| *G | 0.80 | 0.77 | 0.84 |
| 185/230 | 57/74 | 304/360 | |
| T | 0.20 | 0.23 | 0.16 |
| 45/230 | 17/74 | 56/360 | |
| §G/G | 0.67 | 0.67 | 0.70 |
| 77/115 | 25/37 | 127/180 | |
| G/T | 0.27 | 0.19 | 0.28 |
| 31/115 | 7/37 | 50/180 | |
| T/T | 0.06 | 0.14 | 0.02 |
| 7/115 | 5/37 | 3/180 | |