Correlation between pre-test probabilities and mutation prevalence in breast/ovarian families
| Pre-test probability quartiles | |||||
|---|---|---|---|---|---|
| Model | 1st (n=10) | 2nd (n=9) | 3rd (n=9) | 4th (n=9) | Correlation coeficient |
| HCSC | |||||
| Average pre-test probability | 0.16 | 0.28 | 0.44 | 0.77 | 0.85 |
| Prevalence of mutations (95% CI) | 0.20 (0.06 to 0.51) | 0.66 (0.35 to 0.88) | 0.55 (0.28 to 0.81) | 0.89 (0.57 to 0.98) | p=NS |
| LUMC | |||||
| Average pre-test probability | 0.12 | 0.27 | 0.48 | 0.81 | 0.72 |
| Prevalence of mutations (95% CI) | 0.30 (0.11 to 0.60) | 0.55 (0.26 to 0.81) | 0.77 (0.45 to 0.93) | 0.66 (0.35 to 0.88) | p=NS |
| U Penn | |||||
| Average pre-test probability | 0.14 | 0.26 | 0.40 | 0.69 | 0.88 |
| Prevalence of mutations (95% CI) | 40 (0.17 to 0.69) | 0.55 (0.26 to 0.81) | 0.44 (0.19 to 0.73) | 0.89 (0.57 to 0.98) | p=NS |
| HUCH | |||||
| Average pre-test probability | 0.22 | 0.41 | 0.60 | 0.87 | 0.50 |
| Prevalence of mutations (95% CI) | 30 (0.11 to 0.60) | 0.55 (0.26 to 0.81) | 0.88 (0.57 to 0.98) | 0.55 (0.26 to 0.81) | p=NS |
| Frank 2002 | |||||
| Average pre-test probability | 0.21 | 0.41 | 0.51 | 0.72 | 0.933 |
| Prevalence of mutations (95% CI) | 0.10 (0.02 to 0.40) | 0.66 (0.35 to 0.98) | 0.66 (0.35 to 0.98) | 0.88 (0.57 to 0.98) | p=NS |
| Risk counsellor | |||||
| Average pre-test probability | 0.39 | 0.59 | 0.69 | 0.76 | 0.847 |
| Prevalence of mutations (95% CI) | 0.50 (0.24 to 0.76) | 0.55 (0.26 to 0.81) | 0.55 (0.26 to 0.81) | 0.66 (0.35 to 0.88) | p=NS |