Correlation between pre-test probabilities and mutation prevalence in breast only families
| Pre-test probability quartiles | |||||
|---|---|---|---|---|---|
| Model | 1st (n=18) | 2nd (n=18) | 3rd (n=18) | 4th (n=18) | Correlation coeficient |
| HCSC | |||||
| Average pre-test probability | 0.05 | 0.10 | 0.15 | 0.40 | 0.977 |
| Prevalence of mutations (95% CI) | 0 (0.0 to 0.18) | 0.16 (0.05 to 0.38) | 0.22 (0.09 to 0.45) | 0.50 (0.29 to 0.71) | p=0.023 |
| LUMC | |||||
| Average pre-test probability | 0.01 | 0.05 | 0.09 | 0.26 | 0.829 |
| Prevalence of mutations (95% CI) | 0 (0.0 to 0.18) | 0.16 (0.05 to 0.38) | 0.33 (0.16 to 0.56) | 0.38 (0.20 to 0.61) | p=NS |
| U Penn | |||||
| Average pre-test probability | 0.02 | 0.04 | 0.05 | 0.10 | 0.86 |
| Prevalence of mutations (95% CI) | 0 (0.0 to 0.18) | 0.16 (0.05 to 0.38) | 0.33 (0.16 to 0.56) | 0.38 (0.20 to 0.61) | p=NS |
| HUCH | |||||
| Average pre-test probability | 0.02 | 0.06 | 0.11 | 0.23 | 0.86 |
| Prevalence of mutations (95% CI) | 0 (0.0 to 0.18) | 0.27 (0.12 to 0.50) | 0.16 (0.05 to 0.38) | 0.44 (0.24 to 0.66) | p=NS |
| Frank 2002 | |||||
| Average pre-test probability | 0.08 | 0.16 | 0.18 | 0.33 | 0.97 |
| Prevalence of mutations (95% CI) | 0 (0.0 to 0.18) | 0.11 (0.03 to 0.33) | 0.28 (0.13 to 0.51) | 0.50 (0.29 to 0.71) | p=0.03 |
| Risk counsellor | |||||
| Average pre-test probability | 0.24 | 0.37 | 0.49 | 0.67 | 0.81 |
| Prevalence of mutations (95% CI) | 0.06 (0.01 to 0.26) | 0.28 (0.13 to 0.51) | 0.16 (0.05 to 0.38) | 0.39 (0.20 to 0.61) | p=NS |