Correlation between pre-test probabilities and mutation prevalence
| Pre-test probability quartiles | |||||
|---|---|---|---|---|---|
| Model | 1st (n=28) | 2nd (n=28) | 3rd (n=28) | 4th (n=25) | Correlation coeficient |
| HCSC | |||||
| Average pre-test probability | 0.07 | 0.08 | 0.27 | 0.60 | 0.994 |
| Prevalence of mutations (95% CI) | 0.10 (0.03 to 0.26) | 0.17 (0.07 to 0.35) | 0.39 (0.23 to 0.57) | 0.72 (0.54 to 0.85) | p=0.006 |
| LUMC | |||||
| Average pre-test probability | 0.02 | 0.07 | 0.21 | 0.57 | 0.947 |
| Prevalence of mutations (95% CI) | 0.03 (0.0 to 0.17) | 0.25 (0.13 to 0.43) | 0.43 (0.27 to 0.61) | 0.68 (0.49 to 0.82) | p=NS |
| U Penn | |||||
| Average pre-test probability | 0.02 | 0.05 | 0.12 | 0.47 | 0.869 |
| Prevalence of mutations (95% CI) | 0.11 (0.04 to 0.28) | 0.21 (0.10 to 0.39) | 0.46 (0.29 to 0.64) | 0.60 (0.42 to 0.76) | p=NS |
| HUCH | |||||
| Average pre-test probability | 0.03 | 0.10 | 0.24 | 0.65 | 0.944 |
| Prevalence of mutations (95% CI) | 0.07 (0.02 to 0.22) | 0.25 (0.13 to 0.43) | 0.43 (0.27 to 0.61) | 0.64 (0.46 to 0.79) | p=NS |
| Frank 2002 | |||||
| Average pre-test probability | 0.09 | 0.18 | 0.30 | 0.57 | 0.933 |
| Prevalence of mutations (95% CI) | 0 (0 to 0.12) | 0.07 (0.02 to 0.22) | 0.57 (0.39 to 0.73) | 0.76 (0.57 to 89) | p=NS |
| Risk counsellor | |||||
| Average pre-test probability | 0.27 | 0.44 | 0.58 | 0.74 | 0.992 |
| Prevalence of mutations (95% CI) | 0.14 (0.06 to 0.31) | 0.25 (0.13 to 0.43) | 0.43 (0.27 to 0.61) | 0.56 (0.38 to 0.73) | p=0.007 |