Performances in BRCA1 families vBRCA2 families
| Average probability | ROC area | |||||
|---|---|---|---|---|---|---|
| Model | BRCA1 families (n=19) | BRCA2 families (n=18) | p | BRCA2 negative set (n=91) | BRCA1 negative set (n=90) | p |
| NS, not significant. | ||||||
| HCSC | 0.466 | 0.356 | NS | 0.84 (0.74 to 0.90) | 0.80 (0.70 to 0.88) | NS |
| LUMC | 0.47 | 0.236 | 0.006 | 0.86 (0.77 to 0.92) | 0.75 (0.65 to 0.84) | <0.05 |
| U Penn | 0.36 | 0.177 | <0.001 | 0.83 (0.74 to 0.90) | 0.71 (0.60 to 0.80) | <0.05 |
| HUCH | 0.50 | 0.254 | 0.004 | 0.85 (0.76 to 0.92) | 0.68 (0.58 to 0.78) | <0.05 |
| Frank 2002 | 0.51 | 0.33 | 0.005 | 0.89 (0.81 to 0.95) | 0.74 (0.61 to 0.80) | <0.05 |
| Risk counsellor | 0.56 | 0.59 | NS | 0.67 (0.56 to 0.76) | 0.71 (0.61 to 0.80) | NS |