TDT studies of GRM8 SNPs and haplotypes.
| Allele or haplotype | T | NT | χ2 | p value | ||
|---|---|---|---|---|---|---|
| T indicates transmitted and NT indicates not transmitted | ||||||
| Intron 8 SNP | A | 31 | 48 | 3.66 | 0.056 | |
| G | 48 | 31 | 3.66 | 0.056 | ||
| Exon 10 SNP | C | 31 | 52 | 5.31 | 0.021 | |
| T | 52 | 31 | 5.31 | 0.021 | ||
| 3′ SNP | A | 31 | 51 | 4.66 | 0.027 | |
| G | 51 | 31 | 4.66 | 0.027 | ||
| Haplotype of intron 8 and exon 10 SNPs | AC | 20 | 33 | 3.19 | 0.074 | Global |
| AT | 2 | 8 | 3.60 | 0.058 | χ2 = 9.015 | |
| GC | 10 | 10 | 0.00 | 1.000 | df=3, p = 0.029 | |
| GT | 44 | 25 | 5.23 | 0.022 | ||
| Haplotype of exon 10 and 3′ SNPs | CA | 29 | 47 | 4.26 | 0.036 | Global |
| TA + CG | 3 | 6 | 1.00 | 0.317 | χ2 = 7.427 | |
| TG | 48 | 27 | 5.88 | 0.015 | df = 2, p = 0.024 | |
| Haplotype of intron 8, exon 10, and 3′ SNPs | ACA | 19 | 31 | 2.88 | 0.089 | Global |
| ATA + GTA | 0 | 3 | 3.00 | 0.083 | χ2 = 11.28 | |
| ATG | 2 | 7 | 2.78 | 0.095 | df = 4, p = 0.023 | |
| GCA | 10 | 9 | 0.05 | 0.818 | ||
| GTG | 43 | 24 | 5.39 | 0.020 | ||