Observed frequency*† | Odds ratio (95% CI)‡ | ||||||
---|---|---|---|---|---|---|---|
MTHFR 677/1298 genotype | CL/P patients (n=109) | Mothers (n=67) | Fathers (n=45) | Controls (n=202) | CL/P patients | Mothers | Fathers |
*The number of subjects is indicated in parentheses. | |||||||
†NO = not observed. | |||||||
‡ND = not determined. | |||||||
§The 95% CI is not determined owing to the invalidity of the Cornfield 95% confidence limits for odds ratio. | |||||||
CC/AA | 0.30 (33) | 0.25 (17) | 0.42 (19) | 0.33 (66) | 0.89 (0.52 to 1.52) | 0.70 (0.36 to 1.36) | 1.51 (0.74 to 3.06) |
CC/AC | 0.41 (45) | 0.37 (25) | 0.31 (14) | 0.37 (74) | 1.22 (0.73 to 2.01) | 1.03 (0.56 to 1.89) | 0.78 (0.37 to 1.64) |
CC/CC | 0.06 (6) | 0.06 (4) | 0.04 (2) | 0.07 (14) | 0.78 (0.26 to 2.26) | 0.85 (0.23 to 2.91) | 0.62 (0.09 to 3.05) |
CT/AA | 0.20 (22) | 0.16 (11) | 0.16 (7) | 0.20 (40) | 1.02 (0.55 to 1.90) | 0.80 (0.36 to 1.74) | 0.75 (0.28 to 1.91) |
CT/AC | 0.03 (3) | 0.12 (8) | 0.02 (1) | 0.03 (6) | 0.92 (0.18 to 4.26) | 4.43 (1.33 to 15.10) | 0.74§ |
CT/CC | NO | NO | NO | NO | ND | ND | ND |
TT/AA | NO | 0.03 (2) | 0.04 (2) | 0.01 (2) | ND | 3.08 (0.30 to 31.28) | 4.65 (0.45 to 47.82) |
TT/AC | NO | NO | NO | NO | ND | ND | ND |
TT/CC | NO | NO | NO | NO | ND | ND | ND |