Cox proportional hazard model to test significance of clinical covariates and genotypes of ACE polymorphisms as predictors of renal survival
| Variable | p Value | Hazard ratio (95% CI) |
|---|---|---|
| ACEi, angiotensin I converting enzyme inhibitor; ARB, angiotensin receptor blocker; CI, confidence interval. | ||
| Univariate analysis | ||
| Urinary protein excretion >1.0 g/day | <0.0001 | 2.961 (1.719 to 5.101) |
| Hypertension | 0.0014 | 2.102 (1.334 to 3.312) |
| No administration of ACEi or ARB | 0.0014 | 2.281 (1.373 to 3.789) |
| No glucocorticoid therapy | 0.4817 | 0.831 (0.496 to 1.393) |
| Age | 0.1023 | 1.015 (0.997 to 1.033) |
| Sex (male) | 0.8028 | 1.057 (0.682 to 1.639) |
| Genotype | ||
| ACE A2350G | ||
| GG | Referent | 1 |
| AG | 0.4277 | 1.363 (0.634 to 2.931) |
| AA | 0.0352 | 1.599 (1.033 to 2.475) |
| ACE A-240T | ||
| TT | Referent | 1 |
| AT | 0.5490 | 1.239 (0.614 to 2.500) |
| AA | 0.2755 | 1.479 (0.732 to 2.987) |
| ACE I/D | ||
| II | Referent | 1 |
| ID | 0.4007 | 0.732 (0.354 to 1.514) |
| DD | 0.5332 | 1.163 (0.504 to 2.680) |
| Multivariate analysis | ||
| Urinary protein excretion >1.0 g/day | <0.0001 | 3.102 (1.771 to 5.433) |
| Hypertension | 0.0002 | 2.509 (1.537 to 4.097) |
| No administration of ACEi or ARB | <0.0001 | 3.111 (1.797 to 5.385) |
| AA genotype of ACE A2350G | 0.0166 | 1.794 (1.112 to 2.894) |