Comparison of haplotype frequencies between patients with Hirschsprung’s disease and controls, and results of haplotype analysis using the transmission disequilibrium test
| A45A c135G>A | A432A c1296G>A | L769L C2307T>G | Frequencies estimated by EH | TDT | |||||
|---|---|---|---|---|---|---|---|---|---|
| Controls (n = 100) | All patients (n = 87) | p Value | TR | NT | χ2 | p Value | |||
| EH, linkage utility program; NT, chromosomes not transmitted; TDT, transmission disequilibrium test; TR, chromosomes transmitted. | |||||||||
| A | G | G | 0.372 | 0.660 | 0.009 | 43 | 9 | 22.23 | 0.000002 |
| G | A | T | 0.164 | 0.052 | 0.01 | 3 | 16 | 8.89 | 0.0028 |
| G | G | T | 0.322 | 0.147 | 0.03 | 7 | 27 | 11.76 | 0.0006 |
| A | A | G | 0.009 | 0.021 | >0.05 | 3 | 2 | 0.20 | 0.65 |
| A | A | T | 0.004 | 0.011 | >0.05 | 0 | 1 | 1.00 | 0.32 |
| A | G | T | 0.024 | 0.037 | >0.05 | 1 | 2 | 0.33 | 0.56 |
| G | A | G | 0.032 | 0.036 | >0.05 | 4 | 4 | 0.00 | 1.00 |
| G | G | G | 0.071 | 0.035 | >0.05 | 4 | 4 | 0.00 | 1.00 |