Coronary heart disease |
Shami et al. Lancet1991;:
| Case–control study, hospital based | Hospital cases had significantly greater inbreeding coefficients than controls (individuals in population from which they were recruited) |
|
Puzyrev et al. Arctic Med Res1992;:–42
| Ecological study | Increased risk of myocardial ischaemia among endogamous males |
|
Jaber et al.* Am J Med Genet1997;:–8
| Case–control study (self reported exposure and outcome status) | No difference in self reported prevalence among students with or without consanguineous parents |
| Rudan et al (present study), 2003 | Cohort study (with parallel ecological study) | Increased risk associated with greater inbreeding coefficient (relative risk of 1.2 per 3% inbreeding) |
Cancer |
Simpson et al. Am J Obst Gynecol1981;:–36
| Case–control study, population based | Increased risk of breast, endometrial, and ovarian cancer associated with greater inbreeding coefficient in women under 45 years |
|
Lebel & Gallagher. Am J Med Genet1989;:–6
| Case–control study, population based | Increased risk associated with greater inbreeding coefficient, (especially for multiple and early onset cancers) |
|
Shami et al. Lancet1991;:
| Case–control study, hospital based | Hospital cases had significantly greater inbreeding coefficients than controls (individuals in population from which they were recruited) |
|
Rudan. Hum Biol1999;:–87
| Ecological study | Stepwise increase of 20 year cancer incidence associated with greater inbreeding in five island communities |
|
Denic & Bener.*Br J Cancer2001;:–9
| Case–control study, population based (self reported exposure status) | Decreased risk of breast cancer among women who self reported being offspring from consanguineous unions, no effect on cervical cancer |
|
Rudan et al (present study), 2003
| Cohort study (with parallel ecological study) | Increased risk associated with greater inbreeding coefficient (relative risk of 2 per 3% inbreeding) |
Psychiatric disorders |
Abaskuliev & Skoblo. Genetika1975;:–8
| Case–control study, population based | Increased frequency of consanguinity among parents of schizophrenia cases |
|
Sangstad & Odegard. Clin Genet1986;:–75
| Case–control study, population based | No increase in first cousin matings among parents of psychiatric patients (major changes in diagnostic criteria over time reported by authors as important confounder) |
|
Gindilis et al. Genetika1989;:–43
| Ecological study | Severe schizophrenia 2–3 times more prevalent in inbred communities |
|
Rudan et al. (present study) 2003
| Cohort study (with parallel ecological study) | Increased risk associated with greater inbreeding coefficient (relative risk of 2.5 [depression] and 5 [schizophrenia] per 3% inbreeding) |
Alzheimer’s disease |
Vezina et al. Genet Epidemiol1999;:–25
| Case–control study, hospital based | 205 necropsy confirmed cases of late onset Alzheimer’s disease significantly more inbred than controls |
Multiple sclerosis |
Roberts et al. J Epidemiol Community Health1979;:–35
| Case–control population based (with parallel ecological study) | Average inbreeding coefficient greater among cases than controls; increased prevalence in genetic isolate population) |
|
Roberts et al. J Epidemiol Community Health1983;:–5
| Case–control population based (with parallel ecological study) | Average inbreeding coefficient greater among cases than controls; increased prevalence in genetic isolate population) |
Type 2 diabetes |
Jaber et al.* Am J Med Genet1997;:–8
| Case–control study (self reported exposure and outcome status) | No difference in self reported prevalence among students with or without consanguineous parents |
|
Rudan et al. (present study) 2003
| Cohort study (with parallel ecological study) | No consistent increase in risk or prevalence associated with greater inbreeding coefficient |
Gout |
Ombra et al. Am J Hum Genet2001;:–29
| Ecological study | Increased prevalence of hyperuricaemia and uric stones in a highly inbred community |
|
Rudan et al. (present study) 2003
| Cohort study (with parallel ecological study) | Increased risk associated with greater inbreeding coefficient (relative risk of 2.5 per 3% inbreeding) |
Asthma |
Jaber et al.* Am J Med Genet1997;:–8
| Case–control study (self reported exposure and outcome status) | No difference in self reported prevalence among students with or without consanguineous parents |
|
Rudan et al. (present study) 2003
| Cohort study (with parallel ecological study) | Increased risk associated with greater inbreeding coefficient (relative risk of 1.5 per 3% inbreeding) |
Peptic ulcer |
Jaber et al.* Am J Med Genet1997;:–8
| Case–control study (self reported exposure and outcome status) | No difference in self reported prevalence among students with or without consanguineous parents |
|
Rudan et al. (present study) 2003
| Cohort study (with parallel ecological study) | Increased risk associated with greater inbreeding coefficient (relative risk of 3 per 3% inbreeding) |