p values of tests of population stratification and association between the APOE and the TGF-β1 with the phenotypes and the phenotypic variation due to the marker (%)
| APOE | TGF-β1 | |||||
|---|---|---|---|---|---|---|
| Test | Marker | Trait | p value | Marker | Trait | p value |
| All tests were conducted using the program QTDT. | ||||||
| All phenotypes were transformed to normality using Box-Cox procedure implemented in the statistical software MINITAB. | ||||||
| All data were adjusted for age and sex prior to analysis. | ||||||
| Tests for linkage and linkage modelling association did not yield significant results with p>0.05. | ||||||
| The values in parentheses indicate p values from 1000 permutation tests. | ||||||
| Population stratification | ||||||
| GGTC | lean mass | 0.005 | ||||
| Total association | ||||||
| CGTC | fat mass | 0.002 | C+C | lean mass | 0.002 | |
| CGTC | lean mass | 0.003 | T+C | lean mass | 0.008 | |
| CGTC | PFM | 0.004 | ||||
| Within family association | ||||||
| SNP1 | PFM | 0.012 (0.001) | SNP5 | lean mass | 0.005 (0.003) | |
| CGTC | fat mass | 0.023 (0.012) | C+C | lean mass | 0.013 (0.012) | |
| CGTC | PFM | 0.012 (0.006) | T+C | lean mass | 0.008 (0.012) | |
| GGTC | lean mass | 0.001 (0.016) | ||||
| Approximate phenotypic variation due to the marker (%) | ||||||
| SNP1 | PFM | 1.31 | SNP5 | lean mass | 1.25 | |
| CGTC | fat mass | 1.17 | C+C | lean mass | 0.98 | |
| CGTC | PFM | 1.41 | T+C | lean mass | 1.14 | |