Table 2

Genotype and allele frequencies for each SNP marker analysed in this study

Locus symbol (alternative alleles)	Group	n	Allele†		p value		Genotype			p value (Fisher’s exact test)
Locus symbol (alternative alleles)	Group	n	1	2	χ² test	Armitage’s test	1/1	1/2	2/2	p value (Fisher’s exact test)
†The number 1 and 2 indicate, respectively, the major and minor allele.
‡Significant difference in the distribution between the case and control groups after Bonferroni correction.
§The relative risk is 0.39 (95% confidence interval (CI) 0.22 to 0.72) and power for the allele distribution of HTR2C is approximately 87% with α= 0.05.
¶The relative risk is 0.35 (95% CI 0.20 to 0.59) and power for the allele distribution of HTR7 is about 98% with α= 0.05.
HTR1A (G/A)	Patient	82	139	25	0.0117	0.0183	61	17	4	0.011
HTR1A (G/A)	Control	85	125	45	0.0117	0.0183	45	35	5	0.011
HTR2A (C/T)	Patient	84	88	80	0.0421	0.0137	15	58	11	0.044
HTR2A (C/T)	Control	79	65	93	0.0421	0.0137	7	51	21	0.044
HTR2C (C/G)	Patient	85	86	44	0.0005‡§	0.0060†	52	11	22	0.007‡
HTR2C (C/G)	Control	79	99	20	0.0005‡§	0.0060†	60	13	6	0.007‡
HTR5A (A/T)	Patient	91	121	61	0.0574	0.1082	44	33	14	0.153
HTR5A (A/T)	Control	103	155	51	0.0574	0.1082	64	27	12	0.153
HTR6 (C/T)	Patient	87	148	26	0.0961	0.1321	63	22	2	0.261
HTR6 (C/T)	Control	82	128	36	0.0961	0.1321	51	26	5	0.261
HTR7 (G/A)	Patient	88	117	59	< 0.0001‡¶	0.0005‡	46	25	17	0.0025‡
HTR7 (G/A)	Control	84	143	25	< 0.0001‡¶	0.0005‡	64	15	5	0.0025‡