Table 3

TNF −308 and LTA NcoI polymorphisms and biological markers of response to oxidative stress in coal miners in 1994

TNF −308LTA NcoI
11122212 or 22p value*111222p value
Results are expressed as mean (SD).
*12 or 22 v 11.
†Excluding two outliers. Catalase activities were 254 and 303 k/g Hb and they were aged 47 and 49 years. Both outliers had normal x rays at both surveys and low current exposure; one was a smoker, one an ex-smoker.
‡Excluding one outlier (2.29 mmol/l, 47 years, low current exposure, normal x ray both surveys, ex-smoker).
No14952153168995
In erythrocytes
    Catalase (k/g Hb)95 (32)102 (23)116102 (23)0.0899 (15)101 (37)92 (23)0.09
92 (23)†0.0197 (25)†0.2
    Cu++/Zn++ SOD (U/g Hb)145 (31)147 (34)120147 (34)0.7149 (40)148 (32)143 (31)0.4
    GSH-Px (U/g Hb)42.0 (13.6)36.5 (12.2)36.936.5 (12.1)0.0141.3 (10.9)39.7 (14.0)41.1 (13.5)0.8
In plasma
    GSH-Px (U/l)716 (226)681 (215)1202691 (225)0.5760 (209)708 (234)697 (218)0.6
    Total antioxidant concentration (mmol/l)1.36 (0.20)1.34 (0.16)1.541.35 (0.16)0.61.40 (0.15)1.34 (0.17)1.36 (0.21)0.4
1.35 (0.19)‡0.81.35 (0.19)‡0.4
    Se concentration (ng/l)66.3 (19.3)61.2 (18.8)69.861.4 (18.7)0.1167.5 (23.5)64.5 (18.5)64.7 (19.3)0.8