Clinical features of Sotos syndrome in our two patients illustrates their course of growth, development, and facial gestalt
| Patient 1 | Patient 2 | |
|---|---|---|
| *LGA, large for gestational age. †SD, standard deviation, corrected for gestational age. NA, not available. | ||
| Sex | Male | Male |
| Age | 18 months | 29 years |
| Gestation (weeks) | 36 | 38 |
| BW: LGA* | 4200 g (+2.5 SD)† | 4700 g (+3.1 SD)† |
| BL | 54 cm (+2.3 SD)† | 55 cm (+2.5 SD)† |
| OFC at birth | 39 cm (+3 SD) | NA |
| Neonatal hypoglycaemia | + Transient | + Transient |
| Neonatal feeding problems | + Nasogastric feeding for 6 weeks | + Nasogastric feeding for 4 weeks |
| Advanced postnatal growth | ++ 6 mth: 75.5 cm (+2.7 SD) | ++ 5 y: 120 cm (+2.4 SD) |
| 16 mth: 92 cm (+4 SD) | Adult: 186 cm (+1.1 SD) | |
| Advanced bone age | + 9–12 mth at calendar age of 4 mth | + Slightly dysharmonic maturation |
| Macrocephaly | ++ 4 mth: 46.6 cm (+3 SD) | ++ 6 mth: 48 cm (+3 SD) |
| 16 mth: 53.5 cm (+2.8 SD) | 5 y: 56 cm (+3 SD) | |
| Adult: 61.6 cm (+3 SD) | ||
| Large hands | ± 75–95th centile | ++ >>97th centile |
| Large feet | ± 75–95th centile | ++ >>97th centile |
| Increased arm span | NA | + |
| Hypotonia | ++ | ++ Childhood |
| Delayed motor skills | + | + |
| Delayed speech | ± | + |
| Frontal bossing | ++ | ± |
| Midfacial narrowing | + | + |
| Palpebral fissures slanting downwards | − | + |
| Frontoparietal baldness | ++ | − |
| Jaw | Small | Pointed chin, prognathism |
| High arched palate | + | + |