The sequence patterns encoding the poly Q tract
| Sample size | 16 | 32 | 16 | 43 | ||
|---|---|---|---|---|---|---|
| *Group A, breast tumour cell lines; B, primary breast tumours; C, blood DNA from patients carrying mutations in BRCA1/BRCA2 genes; D, general population | ||||||
| †the sequence patterns from the surrounding tissue of breast cancer. | ||||||
| Common sequence patterns | (Gln)n | A* | B* | C* | D* | |
| 1 | (CAG)6CAA(CAG)9(CAACAG)3(CAACAGCAG)2CAA | 29 | 11 | 13 | 8 | 26 |
| 2 | (CAG)6CAA(CAG)8(CAACAG)3(CAACAGCAG)2CAA | 28 | 8 | 20 | 11 | 20 |
| 3 | (CAG)3CAA(CAG)9(CAACAG)3(CAACAGCAG)2CAA | 26 | 4 | 10 | 3 | 14 |
| 4 | (CAG)3CAA(CAG)2CAA(CAG)11(CAACAG)2(CAACAGCAG)2CAA | 29 | 3 | 5 | 1 | 7 |
| Uncommon sequence patterns: | ||||||
| 5 | (CAG)3CAA(CAG)8(CAACAG)3(CAACAGCAG)2CAA | 25 | 1 | 6 | 1 | 1 |
| 6 | (CAG)3CAA(CAG)11(CAACAG)3(CAACAGCAG)2CAA | 28 | — | — | — | 1 |
| 7 | (CAG)3CAA(CAG)2CAA(CAG)9(CAACAG)2(CAACAGCAG)2CAA | 27 | — | 1 | — | — |
| 8 | (CAG)3CAA(CAG)2CAA(CAG)10(CAACAG)2(CAACAGCAG)2CAA | 28 | 2 | 1 | 3 | 2 |
| 9 | (CAG)3CAA(CAG)2CAA(CAG)11(CAACAG)(CAACAGCAG)2CAA | 27 | — | 1 | — | — |
| 10 | (CAG)6CAA(CAG)7(CAACAG)3(CAACAGCAG)2CAA | 27 | 2 | 3 | — | — |
| 11 | (CAG)6CAA(CAG)7(CAACAG)4(CAACAGCAG)2CAA | 29 | — | 1 | — | — |
| 12 | (CAG)6CAA(CAG)11(CAACAG)2(CAACAGCAG)2CAA | 29 | — | 1 | — | 1 |
| 13 | (CAG)6CAA(CAG)10(CAACAG)2(CAACAGCAG)2CAA | 28 | 1 | 3 | — | — |
| 14 | (CAG)6CAA(CAG)9(CAACAG)2(CAACAGCAG)2CAA | 27 | — | 2 | 1 | 1 |
| 15 | (CAG)6CAA(CAG)8(CAACAG)2(CAACAGCAG)2CAA | 26 | 1 | 2 | — | — |
| 16 | (CAG)6(CAACAG)2(CAACAGCAG)2CAA | 17 | — | 1 | — | — |
| 17 | (CAG)5CAA(CAG)9(CAACAG)3(CAACAGCAG)2CAA | 28 | 4 | 2 | — | 1 |
| 18 | (CAG)5CAA(CAG)8(CAACAG)3(CAACAGCAG)2CAA | 27 | 1 | 5 | — | 1 |
| 19 | (CAG)5CAA(CAG)7(CAACAG)3(CAACAGCAG)2CAA | 26 | 1 | — | — | — |
| 20 | (CAG)5CAA(CAG)9(CAACAG)2(CAACAGCAG)2CAA | 26 | — | 1 | — | — |
| 21 | (CAG)5(CAA)2(CAG)8(CAACAG)3(CAACAGCAG)2CAA | 28 | 1 | — | — | — |
| 22 | (CAG)5CAACAGCAA(CAG)7(CAACAG)3(CAACAGCAG)2CAA | 28 | — | — | 1 | — |
| 23 | (CAG)5CGGCAA(CAG)8(CAACAG)3(CAACAGCAG)2CAA | 28 | — | 1 | — | — |
| 24† | (CAG)3CAA(CAG)2CAA(CAG)10CAA(CAACAG)2(CAACAGCAG)2CAA | 29 | — | 1 | — | — |
| 25† | (CAG)3CAA(CAG)2CAA(CAG)7(CAACAG)2(CAACAGCAG)2CAA | 25 | — | 1 | — | — |
| Total number of distinct sequence patterns | 13 | 21 | 8 | 11 | ||