Multivariate probit model for cataracts
| Covariate | Estimated prevalence of cataracts from model (%) | Parameter estimate (SE) | RR | 95% CI |
|---|---|---|---|---|
| RR=relative risk, CI=confidence interval, SE=standard error. | ||||
| Age at diagnosis (per year) | 0.15 (0.58) | 1.00 | 0.98 to 1.02 | |
| Exchangeable dependence (familial correlation) | 0.11 (0.15) | |||
| Type of NF2 mutation | ||||
| Nonsense or frameshift | ||||
| Classical NF2 | 45 | Reference group | Reference group | |
| Somatic mosaic | 17 | −0.82 (0.18) | 0.20 | 0.10 to 0.40 |
| Splice site | 39 | −0.17 (0.19) | 0.71 | 0.34 to 1.50 |
| Missense | 28 | −0.48 (0.26) | 0.38 | 0.14 to 1.08 |
| Large deletion | 28 | −0.47 (0.23) | 0.39 | 0.16 to 0.98 |
| Unfound | ||||
| People with new mutations | ||||
| Age at onset <20 years | 39 | −0.15 (0.15) | 0.74 | 0.40 to 1.36 |
| Age at onset ⩾20 years | 9 | −1.20 (0.28) | 0.09 | 0.03 to 0.28 |
| Inherited cases | 36 | −0.23 (0.34) | 0.63 | 0.16 to 2.45 |