Differentially expressed genes within the Pas 1–4 loci. Since the relevant contrast for these loci is between A/J and C57BL/6J, data for these alone are presented.
| Affymetrix | Gene expression | Lit | Celera | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Probe set | A/J | C57BL/6J | Fold | Z | A | C | Transcript | Position | Description |
| Probe set, Li-Wong full model estimates of gene expression, fold change, and Z score are indicated in columns 1–5. Columns 6 and 7 indicate if the gene has an association with cancer in published reports and, if so, if its observed differential expression is concordant with that of its association. The final columns are the Celera annotation for the transcript. A/J is the susceptible strain in all cases. Candidates (bold) are those having expression concordant with that published | |||||||||
| Pas1 | |||||||||
| 160882_at | 93.5 | 59.9 | 1.6 | 1.6 | mCT16668 | 111,668,200 | Similar to calcium/calmodulin dependent protein kinase I | ||
| 99534_at | 174.9 | 225.2 | 0.8 | −1.0 | mCT20905 | 112,048,000 | Motilin related peptide | ||
| 163377_at | 67.1 | 49.1 | 1.4 | 1.1 | mCT17991 | 119,013,900 | CECR2 (hypothetical) | ||
| 95024_at | 156.8 | 116.8 | 1.3 | 1.1 | Y | mCT17989 | 119,506,600 | Ubiquitin specific protease 18, 15 | |
| 99518_at | 153.6 | 228.0 | 0.7 | −1.6 | mCT15708 | 120,721,600 | Microfibrillar associated protein 5 | ||
| 94912_at | 173.1 | 120.0 | 1.4 | 1.4 | mCT51351 | 121,112,300 | Mitochondrial ribosomal protein S21 | ||
| 99635_at | 232.0 | 153.7 | 1.5 | 1.7 | Y | mCT22535 | 122,858,900 | p33 ING1 homologue | |
| 102282_g_at | 166.7 | 122.9 | 1.4 | 1.2 | mCT22574 | 123,044,600 | CD27L receptor | ||
| 103499_at | 316.6 | 471.3 | 0.7 | −1.8 | Y | mCT6345 | 123,476,500 | von Willebrand factor | |
| 102295_at | 71.3 | 45.9 | 1.6 | 1.5 | mCT6350 | 124,310,300 | Ventricular potassium channel Kv1.5 | ||
| 97504_at | 309.8 | 462.7 | 0.7 | −1.8 | Y | Y | mCT12339 | 124,898,800 | Cyclin D2 |
| 93095_at | 312.3 | 234.2 | 1.3 | 1.2 | Y | Y | mCT12335 | 125,175,000 | High mobilty group protein 2A, 4 |
| 160456_at | 110.6 | 75.4 | 1.5 | 1.4 | Y | Y | mCT50365 | 126,286,900 | Cyclophilin H |
| 97761_f_at | 110.7 | 150.8 | 0.7 | −1.2 | mCT7594 | 128,437,000 | Natural killer cell receptor LY49GDTM | ||
| 93893_f_at | 57.5 | 34.4 | 1.7 | 1.6 | Y | mCT7596 | 128,527,900 | Killer cell lectin-like receptor, subfamily A, member 5 | |
| 103271_at | 63.7 | 45.2 | 1.4 | 1.1 | Y | mCT16910 | 129,272,600 | Low density lipoprotein related protein 6 | |
| 103085_at | 175.8 | 122.7 | 1.4 | 1.4 | mCT20704 | 129,952,300 | Haem binding protein | ||
| 96620_at | 315.0 | 247.0 | 1.3 | 1.1 | mCT21036 | 130,050,900 | Germ cell specific gene 1 | ||
| 160080_r_at | 129.0 | 170.0 | 0.8 | −1.1 | mCT8442 | 131,289,700 | RPL44 | ||
| 113727_at | 58.2 | 27.2 | 2.1 | 2.3 | Y | mCT8441 | 131,320,300 | ATFa associated modulator | |
| 93866_s_at | 1358.4 | 2039.5 | 0.7 | −2.3 | mCT6144 | 131,766,500 | Matrix Gla protein | ||
| 100427_at | 143.4 | 104.2 | 1.4 | 1.2 | Y | Y | mCT6134 | 132,327,700 | Protein tyrosine phosphatase BK |
| 169427_i_at | 50.9 | 33.8 | 1.5 | 1.3 | mCT6276 | 135,543,300 | Riken cDNA 0610025G13 gene | ||
| 106298_r_at | 16.7 | 24.1 | 0.7 | −1.0 | mCT6279 | 136,432,400 | Organic anion transporter | ||
| 160741_at | 151.2 | 234.0 | 0.6 | −1.8 | Y | Y | mCT5581 | 137,106,400 | RecQ protein-like |
| 100035_at | 299.6 | 520.2 | 0.6 | −2.5 | Y | Y | mCT13800 | 139,928,900 | ECA39 protein |
| 97696_r_at | 2534.0 | 2969.4 | 0.9 | −1.0 | mCT13794 | 140,303,300 | RPL7 - human | ||
| 112736_at | 59.6 | 40.6 | 1.5 | 1.3 | Y | Y | mCT11838 | 140,747,600 | Hes related |
| 93250_r_at | 96.4 | 139.1 | 0.7 | −1.4 | Y | mCT11842 | 141,300,800 | Calmodulin 2 | |
| 111826_at | 60.0 | 82.8 | 0.7 | −1.1 | mCT11846 | 141,390,800 | Hypothetical protein FLJ10637 | ||
| 107088_at | 280.1 | 387.1 | 0.7 | −1.4 | mCT11853 | 141,486,800 | Riken cDNA 0610007L03 gene | ||
| 162892_at | 51.4 | 36.2 | 1.4 | 1.1 | mCT6219 | 141,840,000 | Sterile alpha motif (hypothetical) | ||
| Pas2 | |||||||||
| 165371_i_at | 48.6 | 70.1 | 0.7 | −1.2 | mCT18471 | 23,311,090 | Trefoil factor 3, intestinal | ||
| 115002_at | 87.7 | 65.3 | 1.3 | 1.0 | mCT18484 | 23,550,270 | Glycerol 3-phosphate permease | ||
| 97486_at | 95.4 | 137.3 | 0.7 | −1.4 | Y | mCT15017 | 23,861,140 | U2AF 35 kDa subunit | |
| 114243_at | 69.7 | 46.6 | 1.5 | 1.4 | mCT15014 | 24,026,930 | Myocardial SNF1-like kinase | ||
| 110328_at | 76.1 | 53.8 | 1.4 | 1.2 | mCT14905 | 24,696,870 | Riken cDNA 2310021J05 | ||
| 102689_at | 468.9 | 369.2 | 1.3 | 1.1 | Y | Y | mCT22852 | 26,406,370 | Tapasin |
| 95158_at | 530.0 | 729.0 | 0.7 | −1.6 | Y | Y | mCT22857 | 26,425,580 | KE2 |
| 102992_at | 123.6 | 167.0 | 0.7 | −1.2 | Y | Y | mCT22855 | 26,485,130 | H2-K region expressed gene 6 |
| 103616_at | 211.7 | 156.2 | 1.4 | 1.2 | mCT22850 | 26,497,970 | Procollagen, type XI, alpha 2 | ||
| 103035_at | 110.7 | 152.8 | 0.7 | −1.2 | mCT22863 | 26,634,000 | TAP1-g7 | ||
| 104429_at | 101.5 | 141.5 | 0.7 | −1.3 | mCT4541 | 26,743,420 | Histocompatibility 2, O region beta locus | ||
| 92652_at | 103.8 | 71.2 | 1.5 | 1.4 | Y | Y | mCT4529 | 27,211,740 | Notch4 |
| 99652_at | 251.7 | 333.3 | 0.8 | −1.2 | mCT14181 | 27,714,700 | NG26 | ||
| 101416_f_at | 252.8 | 337.3 | 0.7 | −1.3 | mCT14134 | 27,747,330 | BAT4 | ||
| 93840_at | 241.2 | 169.4 | 1.4 | 1.5 | mCT14185 | 27,754,750 | Apolipoprotein M | ||
| 115138_at | 95.2 | 67.5 | 1.4 | 1.2 | Y | Y | mCT17665 | 28,013,740 | MHC psoriasis candidate protein |
| 96212_at | 142.5 | 95.7 | 1.5 | 1.5 | mCT17672 | 28,374,830 | CG16787 gene product | ||
| 95124_i_at | 130.2 | 189.9 | 0.7 | −1.5 | Y | Y | mCT17677 | 28,417,670 | Regulator of cullins 1 |
| 101341_at | 593.1 | 786.9 | 0.8 | −1.4 | Y | Y | mCT23544 | 28,933,180 | Histocompatibility 2, M region locus 9 |
| 103987_at | 63.4 | 45.2 | 1.4 | 1.1 | mCT23038 | 29,279,660 | Myelin/oligodendrocyte glycoprotein precursor | ||
| 93041_at | 95.9 | 71.8 | 1.3 | 1.0 | mCT23261 | 30,162,000 | Mini chromosome maintenance deficient 4 homologue | ||
| 94111_r_at | 57.9 | 123.7 | 0.5 | −2.6 | mCT23260 | 30,325,400 | Similar to ZNF14 (KOX 6) | ||
| 93348_at | 107.8 | 76.3 | 1.4 | 1.3 | Y | mCT49663 | 31,898,120 | Phosphoglycerate kinase 2 | |
| 94730_at | 27.5 | 12.1 | 2.3 | 2.2 | mCT20042 | 31,983,740 | Acidic epididymal glycoprotein 1 | ||
| 114707_at | 8.6 | 13.8 | 0.6 | −1.2 | mCT12126 | 32,320,720 | Riken cDNA 2610528M18Rik | ||
| 116771_at | 90.3 | 66.8 | 1.4 | 1.1 | Y | Y | mCT11932 | 35,423,590 | Ectonucleotide pyrophosphatase/phosphodiesterase 4 |
| 108262_at | 71.8 | 95.8 | 0.7 | −1.0 | mCT11931 | 35,506,800 | Chloride intracellular channel 5 | ||
| 94041_at | 172.7 | 125.7 | 1.4 | 1.3 | Y | Y | mCT5959 | 36,985,830 | Heterogeneous nuclear ribonucleoprotein K |
| 114726_at | 108.3 | 167.2 | 0.6 | −1.7 | Y | Y | mCT13097 | 39,168,870 | CDC5-like |
| 95359_at | 793.5 | 982.0 | 0.8 | −1.1 | mCT12707 | 39,344,620 | Heat shock protein 84 | ||
| Pas3 | |||||||||
| 161384_r_at | 888.5 | 684.5 | 1.3 | 1.3 | mCT15177 | 40,463,040 | Hermansky-Pudlak syndrome protein | ||
| 111898_at | 51.8 | 35.7 | 1.5 | 1.2 | mCT16304 | 41,789,800 | Hypothetical protein FLJ10998 | ||
| 94065_at | 98.7 | 70.0 | 1.4 | 1.2 | mCT9896 | 42,071,970 | Acyl-CoA desaturase 1 | ||
| 97389_at | 78.6 | 106.6 | 0.7 | −1.1 | Y | Y | mCT1056 | 42,740,910 | cdc25 homologue A ( S cerevisiae ) |
| 115138_at | 95.2 | 67.5 | 1.4 | 1.2 | Y | Y | mCT14682 | 43,709,310 | Semaphorin 4G |
| 102796_at | 116.0 | 158.5 | 0.7 | −1.2 | mCT10907 | 44,440,830 | Nucleoplasmin 3 | ||
| 107249_at | 29.1 | 20.5 | 1.4 | 1.0 | Y | Y | mCT10892 | 44,950,270 | Golgi specific brefeldin A resistance factor 1 |
| 94334_f_at | 442.1 | 353.8 | 1.2 | 1.0 | mCT22402 | 45,702,150 | 66 kDa neurofilament protein NF-66 | ||
| 113579_at | 75.2 | 99.8 | 0.8 | −1.0 | mCT22401 | 46,183,310 | Hypothetical protein FLJ22559 | ||
| 97819_at | 238.1 | 496.5 | 0.5 | −3.1 | mCT5611 | 46,546,310 | Glutathione-S-transferase-like | ||
| 108925_at | 55.5 | 35.9 | 1.5 | 1.4 | mCT19627 | 47,290,880 | VPS10 domain receptor | ||
| 99162_at | 83.6 | 120.0 | 0.7 | −1.3 | mCT22431 | 52,008,630 | Splicing factor 30,survival of motor neuron related | ||
| 103029_at | 190.6 | 69.2 | 2.8 | 3.4 | Y | mCT22341 | 52,537,490 | Apoptosis protein MA-3 (PDCD4) | |
| 102635_at | 17.2 | 229.6 | 0.1 | −5.6 | mCT19862 | 54,116,940 | Vesicle transport through interaction with t-SNAREs 1 homologue | ||
| 102151_at | 163.0 | 240.4 | 0.7 | −1.6 | Y | Y | mCT19826 | 55,318,310 | Adrenergic receptor, beta 1 |
| 110339_at | 62.5 | 46.1 | 1.4 | 1.0 | mCT19828 | 55,630,530 | Actin binding LIM protein 1, isoform a | ||
| Pas4 | |||||||||
| 169427_i_at | 50.9 | 33.8 | 1.5 | 1.3 | mCT12262 | 83,884,330 | T box transcription factor TBX18 | ||
| 105097_at | 228.3 | 149.0 | 1.5 | 1.7 | mCT19945 | 95,049,700 | Claudin 18 | ||
| 160932_at | 40.8 | 15.1 | 2.7 | 2.7 | Y | Y | mCT19764 | 95,904,200 | Tyrosine kinase adaptor protein 1 |
| 92489_at | 141.7 | 105.5 | 1.3 | 1.1 | Y | Y | mCT19766 | 96,358,630 | Stromal antigen 1 |
| 100101_at | 198.8 | 267.1 | 0.7 | −1.3 | mCT19754 | 96,852,280 | Small nuclear ribonucleoprotein polypeptide A | ||
| 103085_at | 175.8 | 122.7 | 1.4 | 1.4 | Y | Y | mCT15895 | 98,688,030 | Similar to topoIIBP |
| 160326_at | 125.6 | 178.6 | 0.7 | −1.4 | mCT15894 | 98,732,280 | CDV-3B | ||
| 116123_at | 269.5 | 341.6 | 0.8 | −1.1 | mCT3740 | 100,503,100 | Riken cDNA 2310041H06 gene | ||
| 163306_at | 58.4 | 39.7 | 1.5 | 1.3 | mCT3725 | 100,736,700 | Hypothetical protein XP_039534 | ||
| 160352_at | 270.1 | 189.8 | 1.4 | 1.5 | mCT20224 | 101,833,700 | Poly(rC)-binding protein 4 | ||
| 99534_at | 174.9 | 225.2 | 0.8 | −1.0 | Y | Y | mCT15938 | 102,938,800 | G(i) alpha 2 |
| 110292_at | 93.4 | 69.1 | 1.4 | 1.1 | mCT16206 | 102,975,600 | NAT-1 | ||
| 112736_at | 59.6 | 40.6 | 1.5 | 1.3 | mCT16182 | 103,385,700 | Hypothetical protein FLJ12565 | ||
| 94167_at | 196.6 | 250.7 | 0.8 | −1.0 | Y | mCT18729 | 103,642,900 | eNOS | |
| 100444_at | 79.9 | 105.5 | 0.8 | −1.0 | Y | Y | mCT18731 | 103,697,300 | Cyclin dependent kinase 5 |
| 108911_at | 78.3 | 116.1 | 0.7 | −1.4 | Y | Y | mCT18933 | 103,862,400 | SMARC D3 |
| 111826_at | 60.0 | 82.8 | 0.7 | −1.1 | Y | Y | mCT18907 | 104,395,600 | Wiskott-Aldrich syndrome homologue binding protein |
| 105375_at | 8.3 | 13.7 | 0.6 | −1.3 | mCT18909 | 104,513,100 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | ||
| 101115_at | 86.8 | 128.1 | 0.7 | −1.4 | mCT20670 | 105,153,300 | Lactoferrin precursor | ||
| 98482_at | 77.8 | 44.6 | 1.7 | 1.8 | Y | Y | mCT20658 | 105,440,600 | Parathyroid hormone receptor |
| 98254_f_at | 856.3 | 1138.9 | 0.8 | −1.5 | mCT52401 | 106,253,100 | Similar to Ribosomal protein L7a (H sapiens) | ||
| 103647_at | 148.3 | 209.1 | 0.7 | −1.4 | mCT6130 | 108,921,500 | Acid beta-galactosidase | ||
| 115311_at | 42.4 | 26.2 | 1.6 | 1.5 | mCT6129 | 109,441,300 | Related to glycerophosphate dehydrogenase. | ||
| 93880_at | 110.9 | 75.4 | 1.5 | 1.4 | mCT21847 | 112,331,400 | Tbr2 | ||
| 98302_at | 213.4 | 272.5 | 0.8 | −1.0 | mCT19669 | 113,463,800 | Sodium channel, type X, alpha polypeptide | ||