Table 3
Respiratory chain dysfunction in LHON
In vitro
60–
74
In vivo
75–
77
Complex I activity*
Respiratory rate*
MRS*
*% decrease relative to controls.
G3460A
60–80%
30–35%
0%
G11778A
0–50%
30–50%
75%
T14484C
0–65%
10–20%
50%