Polymorphism | AD (n=92) | PD (n=52) | Controls (n=73) |
---|---|---|---|
†p=0.001 (*1/*1 + *1/*2 v *2/*2). | |||
n, number of subjects genotyped; frequencies shown in parentheses. | |||
IL1A (−889) | |||
*1/*1 | 42 (0.46) | 28 (0.54) | 33 (0.45) |
*1/*2 | 39 (0.42) | 20 (0.38) | 29 (0.40) |
*2/*2 | 11 (0.12) | 4 (0.08) | 11 (0.15) |
*1 | 123 (0.67) | 76 (0.73) | 95 (0.65) |
*2 | 61 (0.32) | 28 (0.27) | 51 (0.35) |
IL1B (−511) | |||
*1/*1 | 35 (0.38) | 25 (0.48) | 24 (0.32) |
*1/*2 | 47 (0.51) | 25 (0.48) | 30 (0.41) |
*2/*2 | 10 (0.11) | 2 (0.04)† | 19 (0.26) |
*1 | 117 (0.63) | 75 (0.72) | 78 (0.53) |
*2 | 67 (0.36) | 29 (0.28) | 68 (0.47) |
IL1RN (VNTR) | |||
*1/*1 | 47 (0.51) | 28 (0.54) | 30 (0.41) |
*1/*2 | 30 (0.33) | 19 (0.36) | 30 (0.41) |
*2/*2 | 8 (0.09) | 0 (0.00) | 9 (0.12) |
*1/*3 | 5 (0.05) | 3 (0.06) | 2 (0.03) |
*2/*3 | 2 (0.02) | 1 (0.02) | 1 (0.01) |
*2/*4 | 0 (0.00) | 1 (0.02) | 1 (0.01) |
*1 | 129 (0.70) | 78 (0.75) | 92 (0.63) |
*2 | 48 (0.26) | 21 (0.20) | 50 (0.34) |
*3 | 7 (0.04) | 4 (0.04) | 3 (0.02) |
*4 | 0 (0.00) | 1 (0.01) | 1 (0.01) |