Pedigree No* | Mean head circumference† | No of affecteds in each sibship‡ | Loci that were homozygous or concordant for each pedigree§ |
---|---|---|---|
*The families are numbered sequentially based upon their chronological ascertainment into the study. | |||
†The mean head circumference for the affected subjects in each family is given as a standard deviation from the age and sex norm. | |||
‡The number of affected subjects is given by sibships, for example, two sibs and a cousin would be represented as “2+1”, and only includes those assessed as affected by the authors and in whom genotyping was performed. | |||
§The MCPH locus to which each family is most likely to be linked was derived from the genotyping results as follows: if all affected member(s) of a family had the same homozygous haplotype for a MCPH locus the family was designated linked; if the affected members had different heterozygous marker results or different homozygous haplotypes the family was regarded as not linked; and if all affected subjects had identical concordant, but heterozygous, haplotypes the family were not regarded as proven linked to the locus but noted as concordant. | |||
1 | −7 | 2+2 | MCPH3 |
2 | −5 | 1+1 | MCPH5 |
3 | −4 | 4 | None |
4 | −4 | 2 | MCPH5 |
5 | −11 | 1 | MCPH5 |
6 | −6 | 2 | MCPH2 |
7 | −4 | 1 | MCPH3 |
8 | −7 | 1 | MCPH2 |
9 | −6 | 1 | MCPH5 |
10 | −4 | 2+1 | MCPH2 |
11 | −12 | 1 | MCPH2 |
12 | −11 | 3 | MCPH5 |
13 | −6 | 2 | None |
14 | −4 | 2+1 | None |
15 | −6 | 2 | MCPH5 |
16 | −7 | 2+1 | MCPH5 |
17 | −4.5 | 2 | None |
18 | −7 | 2+2+1 | MCPH1 |
19 | −7.5 | 2 | MCPH5 |
20 | −8.5 | 2 | MCPH5 |
21 | −8 | 3 | MCPH5 |
22 | −8 | 1+1 | MCPH5 |
23 | −6 | 3 | Concordant for MCPH3 |
24 | −10 | 2 | MCPH1 |
25 | −6 | 2+1 | MCPH2 |
26 | −5 | 1 | MCPH5 |
27 | −6.5 | 2+2+1+1 | MCPH2 |
28 | −7.5 | 1+1 | None |
29 | −10 | 1 | MCPH5 |
30 | −9 | 1+1+2+3+1 | MCPH2 |
31 | −4 | 3+1+1 | None |
32 | −5 | 2 | Concordant for MCPH4 |
33 | −10 | 2+1 | MCPH5 |
34 | −6 | 2 | Concordant for MCPH3 |
35 | −7.5 | 2 | MCPH2 |
36 | −9 | 2+2 | None |
37 | −5 | 3+1+1 | None |
38 | −9 | 1+1+1 | MCPH5 |
39 | −8 | 2 | None |
40 | −4.5 | 1+1 | None |
41 | −9.5 | 2 | MCPH5 |
42 | −10 | 1 | MCPH5 |
43 | −6 | 2 | Concordant for MCPH3 |
44 | −6 | 3+1 | MCPH5 |
45 | −5 | 1 | None |
46 | −9 | 2 | MCPH5 |
47 | −6 | 3 | MCPH5 |
48 | −6 | 2 | MCPH5 |
49 | −5 | 1 | MCPH2 and MCPH3 |
50 | −6 | 1 | MCPH2 |
51 | −4 | 1 | None |
52 | −5 | 1 | None |
53 | −4 | 1 | MCPH2 |
54 | −6 | 2 | MCPH5 |
55 | −9 | 2+1 | MCPH5 |
56 | −9 | 1+5+4+2 | MCPH5 |