Four cases
| Case 1 | Case 2 | Case 3 | Case 4 | |
|---|---|---|---|---|
| Major criteria | ||||
| Severe floppiness at birth with later improvement | Yes, some | Yes | Yes | Yes |
| Poor suck at birth with later improvement | Yes, some | Yes | Yes | Yes |
| Difficulty feeding at birth | Yes | Yes | Yes | Yes |
| Obesity during childhood (age when noticed) | Yes (2) | Yes (3) | Yes (1.25) | Yes (8) |
| Hypogonadism with any of the following, depending on age: | Yes | Yes | No | Yes |
| Males | ||||
| Undescended testes, surgery on testes, decreased | No | Yes | No | |
| facial and body hair, lack of voice change/age at voice change, early pubertal signs | Yes | Yes | No | |
| Females | ||||
| Does/did she have periods (no if only when on pill), age of first period, how many periods per year early pubertal signs | No | |||
| Learning difficulties | Yes | Yes | Yes | No MR |
| Tendency to overeat/obsession with food (from age) | Yes (2.5) | Yes (2) | Yes (2) | No |
| Deletion 15q11-13 on high resolution (>650 bands) or other | Yes | No | No | Yes |
| cytogenetic/molecular abnormality of the PWS chromosome | del 15q12 | del on 6 | Small del | |
| region, including maternal disomy | Meth normal | Meth normal | Meth normal | Meth PWS |
| Minor criteria | ||||
| Decreased movement of baby during pregnancy | Yes | Yes | Yes | Yes |
| Weak cry or inactivity as a baby | Yes | Yes | Some | Yes |
| Frequency and severity of any: temper tantrums, repetitive questioning, obsessional behaviour, violent/aggressive behaviour, fluctuations in mood, argumentative, lying, stealing, stubborn, any other behaviour problems | 6 | 9 | 8 | 2 |
| Disturbed or noisy sleep | Yes | Yes | Yes | No |
| Short height | No? | Yes | No | Yes |
| Growth hormone ever | No | Yes | No | Yes |
| Hypopigmentation, fair skin and hair compared to family | Sandy hair | Fair skin | No | No |
| Small hands or feet | Yes | Yes | Hands | Hands |
| Eye problems (short sight, long sight, squint) | Yes | Yes | Yes | No |
| Thick saliva with crusting at corners of mouth | No | No | No | No |
| Difficulty with articulating words | Yes | Yes | Yes | Yes |
| Skin picking | Yes | Yes | Yes | Some |
| Supportive findings | ||||
| High pain threshold | Yes | Yes | Yes | Some |
| Decreased vomiting. Ever vomited: frequency | Little | Little | Little | Never |
| Not feeling hot or cold: abnormal temperature response | Yes | Yes | ? | ? |
| Scoliosis or spinal curvature | No | No | No | No |
| Unusual skill with jigsaw puzzles | Yes | No | No | Yes |