Table 2

Incidence of female breast cancer per 10⁵ per annum by age of relative and BRCA2 status. Results from a model based on Poisson regression

	BRCA2 positive proband: degree of relatedness
Age of relative	“0” degree*	1st degree	2nd degree	3rd degree	BRCA2 negative persons
*Extrapolation to 100% sharing of genes.
25–29	47	32	22	15	4
30–34	63	42	29	19	6
35–39	516	350	237	160	53
40–44	969	656	444	301	114
45–49	1380	935	633	428	185
50–54	1306	884	599	405	199
55–59	1553	1052	712	482	270
60–64	1787	1210	819	554	354
65–69	1603	1085	735	498	363
70–74	999	676	458	310	258
75–79	1070	724	491	332	314
80–84	876	593	402	272	294
85–89	796	539	365	247	304
Cumulative incidence
70 years	46%	31%	21%	14%	7.7%
90 years	65%	44%	30%	20%	13.6%