BRCA2 mutation screening | BRCA1 mutation screening* | |||
---|---|---|---|---|
No of families | No of families with mutations (%) | No of families | No of families with mutations (%) | |
*Breast/ovarian cancer families and BRCA1 mutations have been described previously.17–19 | ||||
†The average age of diagnosis of female breast cancer was 48.3 years in the BRCA2 positive families, 39.7 years in the BRCA1 positive families, and 50.6 years in the mutation negative families. The average age of diagnosis of ovarian cancer was 55.5 years in the BRCA2 group, 52.9 years in the BRCA1 group, and 50 years in the mutation negative group. | ||||
‡Including one previously identified BRCA1 mutation (U Hamann, unpublished data). | ||||
All families† | 68 | 8 (12) | 74 | 13‡ (18) |
Breast/ovarian cancer families | 17 | 4 (24) | 23 | 6 (26) |
Average age of diagnosis of breast cancer (y) | ||||
<40 | 4 | 1 (25) | 8 | 4 (50) |
40–49 | 5 | 2 (40) | 6 | 1 (17) |
≥50 | 8 | 1 (13) | 9 | 1 (11) |
Average age of diagnosis of ovarian cancer (y) | ||||
<40 | 1 | 0 (0) | 1 | 0 (0) |
40–49 | 5 | 0 (0) | 8 | 3 (38) |
≥50 | 8 | 2 (25) | 11 | 3 (27) |
Unknown | 3 | 2 | 3 | |
Breast cancer families | 51 | 4 (8) | 51 | 7 (14) |
Female and male breast cancer | 4 | 0 (0) | 3 | 0 (0) |
Female breast cancer | 47 | 48 | ||
No of breast cancer patients | ||||
3 | 21 | 2 (10) | 20 | 2 (10) |
4 | 13 | 1 (8) | 15 | 3 (20) |
5+ | 13 | 1 (8) | 13 | 2 (15) |
Laterality | ||||
Unilateral | 34 | 0 (0) | 33 | 3 (9) |
Bilateral | 13 | 4 (31) | 15 | 4 (27) |
Average age of diagnosis (y) | ||||
<40 | 2 | 0 (0) | 6 | 4 (66) |
40–49 | 18 | 2 (11) | 17 | 3 (18) |
≥50 | 27 | 2 (7) | 25 | 0 (0) |